Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : May | Volume : 12 | Issue : 5 | Page : LC05 - LC10

Acute Kidney Injury: Prevalence and Outcomes in Southern Indian Population

Zabiuddin Ahad Mohammed, Anna Asa Suresh, Prasanna Kumar, Ravindra Prabhu Attur

1. Student, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India. 2. Student, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India. 3. Assistant Professor, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India. 4. Head and Professor, Department of Nephrology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Correspondence Address :
Dr. Prasanna Kumar,
Assistant Professor, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India.

Abstract

Introduction: Acute Kidney Injury (AKI) is characterised by a rapid reduction in the kidney function and gets effected to varying degrees based on the aetiology. An AKI increases the chances of Chronic Kidney Disease (CKD) if not treated properly or assessed timely.

Aim: To identify the common aetiologies and to assess the prognosis and outcomes of AKI in a tertiary care centre in southern India.

Materials and Methods: A retrospective observational study was conducted, in a tertiary care teaching hospital over a period of six months (August 2015 to February 2016), upon receiving approval from Institutional Ethics Committee (KH IEC 392/2015). Data of patients aged =18 years admitted during JanuaryDecember 2012 were collected from the medical records using the ICD10 code for AKI, unspecified (N17.9). Patients with renal transplantation and chronic dialysis were excluded. Age, gender, aetiology, management, and association between treatment and outcome were analysed using descriptive statistics, univariate and multivariate logistic regression and chi square test.

Results: Among 528 patients, with AKI, male predominance of 72.7% (n=384) and median {Interquartile Range (IQR)} age of 56 (20) years was observed. Prevalence of AKI was found to be 8.36/1,000 people. Community Acquired-AKI (CA-AKI) and Hospital Acquired-AKI (HA-AKI) accounted for 35% (n=185) and 65% (n=343) respectively. CKD 23% (n=79) and sepsis 22.4% (n=77) were the major aetiologies among CA-AKI whereas sepsis 49.2% (n=91) and CKD 11.9% (n=22) were the majorities among the HA-AKI. Chi square test for association between treatment and outcomes (recovery) showed a statistically significant relationship with dextrose normal saline (?2 =10.96, p<0.05), sodium bicarbonate (?2 =7.63, p<0.05), dopamine (?2 =112.14, p<0.05), calcium gluconate (?2 =17.20, p<0.05) and haemodialysis (?2 =12.13, p<0.05). Complete recovery in 64% (n=341) whereas 16% (n=82) of patients died.

Conclusion: Sepsis and CKD were seen to be the leading aetiologies. Male gender with AKI is more likely to develop CKD. AKI with Diabetes Mellitus (DM), sepsis or Urinary Tract Infection (UTI) might worsen the prognosis. Fluid replenishment shows to improve the prognosis.

Keywords

Aetiologies, Chronic kidney disease, Sepsis

How to cite this article :

Zabiuddin Ahad Mohammed, Anna Asa Suresh, Prasanna Kumar, Ravindra Prabhu Attur. ACUTE KIDNEY INJURY: PREVALENCE AND OUTCOMES IN SOUTHERN INDIAN POPULATION. Journal of Clinical and Diagnostic Research [serial online] 2018 May [cited: 2018 Aug 20 ]; 12:LC05-LC10. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=May&volume=12&issue=5&page=LC05-LC10&id=11486

DOI and Others

DOI: 10.7860/JCDR/2018/32512.11486

Date of Submission: Sep 12, 2017
Date of Peer Review: Nov 20, 2017
Date of Acceptance: Feb 23, 2018
Date of Publishing: May 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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