Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2018 | Month : June | Volume : 12 | Issue : 6 | Page : ED04 - ED05

Nasolabial Extraosseous Benign CD68+ Giant Cell Neoplasm with Low Malignant Potential

Ashok kumar kapoor, Surbhi Rajauria, Akanksha Singh, Anil Kumar Verma

1. Pathologist, Department of Pathology, RML Mehrotra Pathology Ltd., Nirala Nagar, Lucknow, Uttar Pradesh, India. 2. Pathologist, Department of Pathology, RML Mehrotra Pathology Ltd., Nirala Nagar, Lucknow, Uttar Pradesh, India. 3. Senior Technician, Department of Pathology, RML Mehrotra Pathology Ltd., Nirala Nagar, Lucknow, Uttar Pradesh, India. 4. Assistant Professor, Department of Pathology, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India.

Correspondence Address :
Dr. Ashok Kumar Kapoor,
B-171, Nirala Nagar, Lucknow-226020, Uttar Pradesh, India.
E-Mail: drashokkapoor2016@gmail.com

Abstract

The present case report highlights the histopathological features of a small nasolabial tumour in a 22-year-old female. The tumour was adequately excised. It consisted of proliferated Mononuclear Spindle (MNS) cells admixed with numerous giant cells. Tumour was located in superficial subcutaneous tissue. Immunohistochemical (IHC) examination showed strong positivity of giant cells for anti-CD68+ antibody, suggesting their origin from Monocyte-macrophage (MŲ) cells. Both MNS cells and giant cells showed strong positive staining with anti-vimentin antibody. In addition, MNS cells did not show nuclear atypia and mitoses. It was finally diagnosed as a Giant Cell Tumour of Soft Tissue (GCT-ST). It is a highly cellular neoplasm. Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) expression by MNS cells stimulates osteoclast formation, resorption and osteolysis associated with this tumour. A benign course is expected after complete excision of this tumour.

Keywords

Mononuclear spindle cells, Spindle cell tumour, Subcutaneous

How to cite this article :

Ashok kumar kapoor, Surbhi Rajauria, Akanksha Singh, Anil Kumar Verma. NASOLABIAL EXTRAOSSEOUS BENIGN CD68+ GIANT CELL NEOPLASM WITH LOW MALIGNANT POTENTIAL. Journal of Clinical and Diagnostic Research [serial online] 2018 June [cited: 2018 Jun 24 ]; 12:ED04-ED05. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=June&volume=12&issue=6&page=ED04-ED05&id=11678

DOI and Others

DOI: 10.7860/JCDR/2018/35022.11678

Date of Submission: Dec 01, 2017
Date of Peer Review: Feb 19, 2018
Date of Acceptance: Mar 26, 2018
Date of Publishing: Jun 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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