Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 23709

Original article / research
Year : 2018 | Month : June | Volume : 12 | Issue : 6 | Page : BC21 - BC24

Atherogenic Index of Plasma an Indicator for Predicting Cardiovascular Risk in Addition to Endothelial Dysfunction in Type 2 Diabetic Subjects

Siva Prasad Palem, Philips Abraham

1. Assistant Professor, Department of Biochemistry, Basaveshwara Medical College, Chitradurga, Karnataka, India. 2. Professor, Department of Biochemistry, Al-Azhar Medical College and Super Speciality Hospital, Thodupuzha, Idukki, Kerala, India.

Correspondence Address :
Dr. Siva Prasad Palem,
Assistant Professor, Department of Biochemistry, Basaveshwara Medical College, Chitradurga-577501, Karnataka, India.
E-mail: sp.biocom@yahoo.co.in

Abstract

Introduction: Prevalence of Cardiovascular Disease (CVD) in diabetic subjects is higher than that in the general population. Dyslipidaemia is a known atherogenic factor which causes vascular complications in both general and diabetic population. Antherogenic Index of Plasma (AIP) is the ratio of triglyceride to HDL, which is a major factor for detecting cardiovascular risk. Endothelial Dysfunction (ED) is the primary stage for the development of atherosclerosis and vascular complications.

Aim: To estimate whether AIP will be a strong indicator for predicting cardiovascular risk in addition to endothelial dysfunction in type 2 diabetes mellitus.

Materials and Methods: The study was conducted on 80 subjects with age group 38-60 years. Among these subjects 40 were type 2 diabetic subjects and remaining 40 were age and sex matched healthy controls. Blood sugar, lipid profile were measured by using well established methods in fully autoanalyser. Lipoprotein ratios were calculated by using lipid profile values in Microsoft Excel. AIP was calculated by using formula log (TG/HDL-c). Nitric Oxide (NO) was estimated by kinetic cadmium reduction method in spectrophotometer. Statistical analysis was done by using SPSS software version 21.0, “Kruskal-Wallis” test was performed for variables between the study groups.

Results: Significantly high levels of Triglyceride (TG) and LDL (151.75±62.38 and 181.70±45.72) were observed in type 2 diabetic subjects than healthy controls (121.15±72.72 and 119.13±34.13). The study also observed significantly high levels of TG/HDL and LDL/HDL ratio’s and AIP in type 2 diabetic subjects. Significantly lower level of NO was observed in diabetic subjects; NO is negatively correlated with AIP, TG, LDL, TG/HDL and LDL/HDL.

Conclusion: We found negative correlation of AIP with NO. Hence, estimation of NO in addition to AIP can be a strong indicator for predicting CVD in type 2 diabetic subjects.

Keywords

High density lipoprotein, Low density lipoprotein, Nitric oxide, Triglyceride

How to cite this article :

Siva Prasad Palem, Philips Abraham. ATHEROGENIC INDEX OF PLASMA AN INDICATOR FOR PREDICTING CARDIOVASCULAR RISK IN ADDITION TO ENDOTHELIAL DYSFUNCTION IN TYPE 2 DIABETIC SUBJECTS. Journal of Clinical and Diagnostic Research [serial online] 2018 June [cited: 2018 Aug 16 ]; 12:BC21-BC24. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=June&volume=12&issue=6&page=BC21-BC24&id=11690

DOI and Others

DOI: 10.7860/JCDR/2018/31834.11690

Date of Submission: Jul 22, 2017
Date of Peer Review: Oct 05, 2017
Date of Acceptance: Mar 15, 2018
Date of Publishing: Jun 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • SCOPUS
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)
  • www.omnimedicalsearch.com