Comparative Evaluation of Propofol Fentanyl, Propofol-Midazolam and Propofol-Dexmedetomidine on Haemodynamic and Postoperative Recovery for Endoscopic Retrograde CholangiopancreatographyCorrespondence Address :
Dr. Vinit Kumar Srivastava,
Department of Anesthesia, Apollo Hospitals, Bilaspur, Chhattisgarh, India.
Introduction: Adequate patient sedation is mandatory for Endoscopic Retrograde Cholangiopancreatography (ERCP). Recent studies indicate that propofol and combination of midazolam or fentanyl or dexmedetomidine is superior to propofol alone in terms of haemodynamic stability, sedation efficacy and recovery parameter.
Aim: The present study compared the efficacy of propofolfentanyl, propofol-midazolam and propofol-dexmedetomidine on haemodynamic and postoperative recovery in ERCP patients.
Materials and Methods: A total of 105 patients were randomly assigned to three groups. Group I received fentanyl 1 mcg/ kg over 10 min, followed by propofol loading dose 1-2 mg/kg before procedure and maintenance 1-5 mg/kg/h throughout the procedure. Group II received midazolam 0.04 mg/kg over 10 minute, followed by the same dose of propofol and group III received dexmedetomidine 1 mcg/kg over 10 minute, followed by the same dose of propofol throughout the procedure. Heart rate, blood pressure and oxygen saturation were recorded at preoperative, after study drug, after induction, during procedure and after 5 minute of end of the procedure. Time to achieve Modified Aldrete Score of 9-10, endoscopistís satisfaction and patientsís satisfaction (according to Visual Analog Scale 0-100 mm) were also recorded. Patient characteristic data were analysed with one-way analysis of variance (ANOVA) and Chi-square test. Haemodynamic parameters were compared with ANOVA. Satisfaction score was analysed by the Kruskal-Wallis test.
Results: Demographic data of all the groups were comparable. In group III, there was no significant increase in heart rate and blood pressure values during the procedure (p>0.05), while in group I and II there was a significant change in heart rate and blood pressure at various intervals. Endoscopistís satisfaction was significantly more in group I and group III compared to group II (p<0.05), but patientsís satisfaction was similar among the groups (p>0.05).
Conclusion: Dexmedetomidine-propofol and fentanylpropofol combination are more effective than midazolampropofol for maintaining the haemodynamic stability in ERCP. Dexmedetomidine is most appropriate adjuvant because it reduces the pain level and the amount of propofol to be administered to the greatest extent and is not different from other agents in terms of satisfaction score and side effects.
Bispectral index, Sedation, Visual analog score
Vinit Kumar Srivas Tava , Devendra Singh, Sanjay Agrawal,
Saima Khan, Ankita Gupta, Roop Das Miree
. COMPARATIVE EVALUATION OF PROPOFOL
FENTANYL, PROPOFOL-MIDAZOLAM AND
HAEMODYNAMIC AND POSTOPERATIVE
RECOVERY FOR ENDOSCOPIC RETROGRADE
CHOLANGIOPANCREATOGRAPHY. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jun 22 ]; 12:UC01-UC05. Available from
Date of Submission: Sep 05, 2017
Date of Peer Review: Nov 13, 2017
Date of Acceptance: May 01, 2018
Date of Publishing: Jul 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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