Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : ED06 - ED08

Low Grade Central Osteosarcoma-A Diagnostic Challenge

Parampalli Srinivas Srilatha, Ranjini Kudva, Simanchal P Mohanty

1. Associate Professor, Department of Pathology, Kasturba Medical College, Manipal, Karnataka, India. 2. Professor, Department of Pathology, Kasturba Medical College, Manipal, Karnataka, India. 3. Professor, Department of Orthopaedics, Kasturba Medical College, Manipal, Karnataka, India.

Correspondence Address :
Dr. Parampalli Srinivas Srilatha,
Associate Professor, Department of Pathology, Kasturba Medical College, Manipal-576104, Karnataka, India.
E-mail: srilatha.ps@manipal.edu

Abstract

Low Grade Central Osteosarcoma (LGCO) is a rare intramedullary and well differentiated variant of osteosarcoma with a better prognosis than the more common conventional variant. It was first described by Unni et al., in 1977. Due to its subtle histological features of malignancy, it is difficult to diagnose on biopsy. Even in the resection specimen it can be mistaken for lesions like fibrous dysplasia, desmoplastic fibroma, parosteal osteosarcoma and fibrosarcoma. Adequate sampling of the tumour is essential to arrive at a correct diagnosis. Histological features such as cytological atypia, mitotic activity, permeation into the bone marrow, entrapment of the native bone, cortical disruption and soft tissue extension will help in the diagnosis of this tumour. We report a case of a 30-year-old man who presented with pain in the right hip of three months duration. On radiological evaluation, a lytic lesion was noted in the upper part of right femur and a possible diagnosis of locally aggressive giant cell tumour of bone was proposed. On histopathological study of the resected upper part of the right femur, a diagnosis of LGCO was rendered.

Keywords

Bone tumour, Intramedullary, Well differentiated

How to cite this article :

Parampalli Srinivas Srilatha, Ranjini Kudva, Simanchal P Mohanty. LOW GRADE CENTRAL OSTEOSARCOMA-A DIAGNOSTIC CHALLENGE. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jul 21 ]; 12:ED06-ED08. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=July&volume=12&issue=7&page=ED06-ED08&id=11822

DOI and Others

DOI: 10.7860/JCDR/2018/35819.11822

Date of Submission: Feb 01, 2018
Date of Peer Review: Mar 25, 2018
Date of Acceptance: Apr 27, 2018
Date of Publishing: Jul 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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