Impact of Nano Hydroxyapatite, Nano Silver Fluoride and Sodium Fluoride Varnish on Primary Teeth Enamel Remineralization: An In Vitro StudyCorrespondence Address :
Dr. Elmira Niazi,
Postgraduate Student, Department of Paediatric Dentistry, School of Dentistry, Shiraz University of Medical Sciences,
Ghasrodasht St, Shiraz, Fars, Iran.
Introduction: Dental caries is still prevailing worldwide, although different anti caries products have been introduced. Each remineralizing agent has its own shortcomings. Therefore, looking for new agents to have benefits of previous ones with lesser side effects is worthwhile.
Aim: To determine the remineralization ability of NaF varnish, nano-Hydroxyapatite Serum (n-HAP) and Nano Silver Fluoride (NSF) on enamel of primary anterior teeth.
Materials and Methods: Incipient caries were induced in primary sound anterior teeth by storing each specimen in demineralization solution for 72 hours. Then they were randomly divided into four groups of 15 samples each: (1) NaF varnish; (2) n-HAP repairing serum; (3) NSF and (4) no treatment (control). Surface Microhardness (SMH) was assessed with Vickers micro hardness tester before and after demineralization and after 10 days of pH-cycling. A total of 12 random specimens from groups 1 to 4 (3 random samples of each group) were examined by Atomic Force Microscopy (AFM). The SMH values were analysed with one-way and repeated measures ANOVA. Level of significance was set at p=0.05.
Results: Post lesion SMH values significantly decreased in all groups (p<0.001). Post treatment SMH values significantly increased in comparison to post lesion ones (p<0.001) except for control group which was not different statistically (p=0.86). The highest SMH values were observed in NSF group (mean 222.90 ± 28.79). Statistically significant differences were shown between all groups (p<0.05). However, NaF varnish and n-HAP groups were not statistically different (p=0.165). AFM images demonstrated protective layers in all treated groups.
Conclusion: The results of this in vitro study suggest that NSF could have the greatest remineralization efficacy. NaF varnish and n-HAP serum were similar in remineralizing initial caries. Future clinical studies are recommended for selection of the most appropriate remineralizing agent in primary teeth.
Dental caries, Silver compounds, Tooth demineralization
Ali Nozari, Shabnam Ajami, Azade Rafiei, Elmira Niazi. IMPACT OF NANO HYDROXYAPATITE, NANO
SILVER FLUORIDE AND SODIUM FLUORIDE
VARNISH ON PRIMARY TEETH ENAMEL
REMINERALIZATION: AN IN VITRO STUDY
. Journal of Clinical and Diagnostic Research [serial online] 2017 September [cited: 2018 Jan 21 ]; 11:ZC97-ZC100. Available from
Date of Submission: May 13, 2017
Date of Peer Review: Jun 15, 2017
Date of Acceptance: Jul 07, 2017
Date of Publishing: Sep 01, 2017
FINANCIAL OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2016: 132.37
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)