Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : November | Volume : 11 | Issue : 11 | Page : EC05 - EC08

Spectrum of Sinonasal Lesions with Expression of p16 and Ki-67 in Premalignant Lesions and Squamous Cell Carcinomas

Madhumita Paul, Suchandra Ray, Moumita Sengupta, Arunabha Sengupta

1. Resident Doctor, Department of Pathology, Institute of Postgraduate Medical Education and Research, Kolkata, India. 2. Associate Professor, Department of Pathology, Institute of Postgraduate Medical Education and Research, Kolkata, India. 3. Assistant Professor, Department of Pathology, Institute of Postgraduate Medical Education and Research, Kolkata, India. 4. Professor and Head, Department of Otorhinolaryngology, Institute of Postgraduate Medical Education and Research, Kolkata, India.

Correspondence Address :
Dr. Moumita Sengupta,
Flat no A11, Snehaneer Apartment, 1185 Newgaria, Kolkata-700094, India.
E-mail: moumitasengupta83@gmail.com

Abstract

Introduction: Sinonasal masses are heterogeneous group of non-neoplastic and neoplastic lesions originating from epithelial, mesenchymal, haematolymphoid and neuroendocrine cells. Exact categorization and aetiological evaluation by histopathological and additional immunohistochemical examination are essential for individualized treatment.

Aim: To evaluate the clinico-epidemiological variables of sinonasal lesions and to determine the role of Human Papilloma Virus (HPV) infection along with its correlation with Ki-67 level in squamous cell carcinomas and precursor lesions.

Materials and Methods: An observational and cross-sectional study was performed in a tertiary care hospital, in the Department of Pathology in collaboration with the Department of Otorhinolaryngology over 18 months from January 2015 to June 2016 including 87 patients. Haematoxylin and Eosin (H&E) stained sections were examined and reported according to WHO category. During immunohistochemical study with Ki-67 and p16, squamous lesions were categorized as Inflammatory Polyp (IfP), Inverted Papilloma (IvP), Exophytic Papilloma (EP), Squamous Cell Carcinoma arising in pre-existing Inverted Papilloma (IvP with SCC), Squamous Cell Carcinoma (SCC) and Sinonasal Undifferentiated Carcinoma (SNUC).

Results: Among 87 cases, 39(44.83%) non-neoplastic lesions, 21(24.14%) benign neoplastic lesions and 27(31.03%) malignant neoplastic lesions were found. Ki-67 Labelling Index gradually increased from IfP (3.82%) to SNUC (85%). Expression of p16 was highest (50%) in IvP with SCC group and SNUC group than 33.3% in IvP group and SCC group.

Conclusion: Simultaneous evaluation of p16 expression and cell cycle proliferation marker (Ki-67) revealed significant difference. Thus, HPV plays a pivotal role in oncogenesis and malignant transformation in squamous sinonasal lesions.

Keywords

Human Papilloma Virus, Sinonasal mass, Squamous lesions

How to cite this article :

Madhumita Paul, Suchandra Ray, Moumita Sengupta, Arunabha Sengupta. SPECTRUM OF SINONASAL LESIONS WITH EXPRESSION OF P16 AND KI-67 IN PREMALIGNANT LESIONS AND SQUAMOUS CELL CARCINOMAS. Journal of Clinical and Diagnostic Research [serial online] 2017 November [cited: 2018 Jan 21 ]; 11:EC05-EC08. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=November&volume=11&issue=11&page=EC05-EC08&id=10818

DOI and Others

DOI: 10.7860/JCDR/2017/25731.10818

Date of Submission: Nov 30, 2016
Date of Peer Review: Jan 18, 2017
Date of Acceptance: Jul 31, 2017
Date of Publishing: Nov 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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