A Comparative Study of High Sensitivity C-Reactive Protein and Metabolic Variables in Type 2 Diabetes Mellitus with and without NephropathyCorrespondence Address :
Dr. Abid K Shaheer,
MM House, Kuniyil, Kizhuparamba, Malappuram-673639, Kerala, India.
Introduction: Diabetic nephropathy is a serious chronic complication of Type 2 Diabetes Mellitus (T2DM) which impairs the quality of life, leading to increased morbidity and mortality. The high sensitivity C-reactive protein (hs-CRP) is an acute phase reactant which acts as a non-specific systemic marker of inflammation.
Aim: To find out the relationship between serum hs-CRP and metabolic variables in Type 2 diabetic patients with and without nephropathy.
Materials and Methods: The study group consists of 96 subjects that include non-diabetic healthy controls, Type 2 diabetic patients without any complications and patients with diabetic nephropathy. The study group composed of both genders aged 31-70 years and the subjects were reported fasting after 10-12 hour overnight fast. Venous blood and fresh urine samples in the morning were collected from all the study subjects. Data were analysed using Statistical Package for the Social Sciences (SPSS). Independent t-test was used to compare between the groups and Chi square test was used to find out the relationship between serum hs-CRP and metabolic variables.
Results: The results showed a significantly (p<0.05) increasing trend of serum hs-CRP with the degree of microalbumin excretion and the severity of nephropathy in Type 2 diabetic patients. The result showed a significant (p<0.05) relationship between hs-CRP and the metabolic variables like Fasting Blood Glucose (FBG), Post Prandial Blood Glucose (PPBG), Total Cholesterol (TC), Triglycerides (TG), LDL-Cholesterol (LDL-C), TC:HDL-Cholesterol (HDL-C) ratio and estimated Glomerular Filtration Rate (eGFR) and no significance (p>0.05) between hs-CRP and HDL-Cholesterol in both diabetic and diabetic nephropathy subjects.
Conclusion: Hs-CRP was strongly associated with the metabolic variables and predictors of cardiovascular risk in Type 2 diabetes mellitus with and without nephropathy. The hs-CRP might be considered as a predictor or illness indicator for the development of nephropathy and cardiovascular risk in Type 2 diabetic patients.
Dyslipidemia, Hyperglycemia, Inflammation, Insulin resistance
Abid K Shaheer, Jithesh K Tharayil, Parvathi W Krishna. A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN AND METABOLIC VARIABLES IN TYPE 2 DIABETES MELLITUS WITH AND WITHOUT NEPHROPATHY. Journal of Clinical and Diagnostic Research [serial online] 2017 September [cited: 2017 Sep 20 ]; 11:BC01-BC04. Available from
Date of Submission: May 21, 2017
Date of Peer Review: Jun 21, 2017
Date of Acceptance: Aug 08, 2017
Date of Publishing: Sep 01, 2017
FINANCIAL OR OTHER COMPETING INTERESTS: None.
- PubMed Central® (PMC)New
- Academic Search Complete Database
- Chemical Abstracts Service
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Open J-Gate
- Popline (reproductive health literature)