Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : OC39 - OC42

Anti-C1q Antibody is Associated with Renal and Cutaneous Manifestations in Asian Indian Patients with Systemic Lupus Erythematosus

Jayakanthan Kabeerdoss, Nikhil Gupta, Sandhya Pulukool, Hindhumathi Mohan, Gowri Mahasampath, Debashish Danda

1. Lecturer, Department of Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India. 2. PG Registrar, Department of Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India. 3. Associate Professor, Department of Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India. 4. Junior Research Fellow, Department of Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India. 5. Associate Research Officer, Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India. 6. Professor and Head, Department of Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India.

Correspondence Address :
Dr. Debashish Danda,
Professor and Head, Department of Rheumatology, Christian Medical College, Vellore-632004, Tamil Nadu, India.
E-mail: debashisdandacmc@hotmail.com

Abstract

Introduction: C1q play an important role in clearance of immune complexes and apoptotic cell debris. Impaired clearance leads to exposure of C1 native antigen and development of anti-C1q antibody formation. Anti-C1q antibody is well studied in Systemic Lupus Erythematosus (SLE). Significance of anti-C1q Ab in Indian SLE patients and their clinical manifestations is not clear.

Aim: The aim of this study was to investigate associations between anti-C1q antibody and clinical as well as serological markers of SLE.

Materials and Methods: Retrospective study of SLE patients fulfilling either American College of Rheumatology (ACR) 1990 or Systemic Lupus International Collaborating Clinics (SLICC) 2012 classification criteria were recruited from inpatients and outpatients services of the Clinical immunology and Rheumatology Department, Christian Medical College at Vellore, India between March 2013 and January 2015. Anti-C1q antibody was assayed by ELISA (Demeditec Diagnostics GmbH, Germany). Logistic regression analysis was performed to find the association of anti-C1q antibodies with serological and clinical parameters in SLE including Lupus Nephritis (LN).

Results: Sixty nine patients (54.76%) out of 126 SLE patients had LN. Anti-C1q levels were higher in patients with LN as compared to those without (p<0.05). Anti-C1q antibody was also significantly associated with positive C1q immunofluorescence staining in renal biopsy specimens (p<0.05). Overall, renal Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) {OR 1.35 (1.08-1.69)}, low C4 {OR 3.11 (1.04-9.26)} and mucocutaneous manifestation {OR 4.72 (1.38-16.05)} were independently associated with anti-C1q levels in serum.

Conclusion: Renal SLEDAI, low C4 and mucocutaneous manifestations were independently associated with raised anti C1q antibody in SLE patients.

Keywords

Anti nucleosome antibody, Complement C4, Lupus nephritis

How to cite this article :

Jayakanthan Kabeerdoss, Nikhil Gupta, Sandhya Pulukool, Hindhumathi Mohan, Gowri Mahasampath, Debashish Danda. ANTI-C1Q ANTIBODY IS ASSOCIATED WITH RENAL AND CUTANEOUS MANIFESTATIONS IN ASIAN INDIAN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Mar 24 ]; 11:OC39-OC42. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=OC39-OC42&id=9545

DOI and Others

DOI: 10.7860/JCDR/2017/22661.9545



Date of Submission: Jul 12, 2016
Date of Peer Review: Oct 01, 2016
Date of Acceptance: Nov 11, 2016
Date of Publishing: Mar 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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