Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : EC50 - EC53

A Clinicopathological Study of Paediatric Liver Tumours in a Tertiary Care Hospital

Esakki Muthuvel, Vimal Chander Chitra Srinivasan

1. Associate Professor, Department of Pathology, Saveetha Medical College, Chennai, Tamil Nadu, India. 2. Assistant Professor, Department of Pathology, Saveetha Medical College, Chennai, Tamil Nadu, India. 3. Professor and Head, Department of Pathology, Saveetha Medical College, Chennai, Tamil Nadu, India.

Correspondence Address :
Dr. Vimal Chander,
216, Mahatma Gandhi 2nd Street, Thiruverkadu Cooperative Nagar, Chennai - 77, Tamil Nadu, India.


Introduction: Paediatric primary liver tumours are the third largest group of solid abdominal neoplasms in children next to neuroblastoma and Wilms tumour, accounting for about 0.5% to 2% of all paediatric neoplasms, in which hepatoblastoma is the most common.

Aim: The present study was done to estimate the incidence of paediatric liver tumours over a period of five years and also, to study the clinical behaviour, alpha-fetoprotein correlation and histopathological features of paediatric liver tumours.

Materials and Methods: The details of patients treated for paediatric liver tumours for a period of five years were retrospectively retrieved from the tumour board and medical records. The gross features and all the slides were reviewed and the pathologic diagnosis was confirmed and clinicopathological correlation was then done.

Results: A total of 39 paediatric liver tumours were detected during five years, of which 32 (82%) were malignant and seven (18%) were benign with a male to female ratio of 1:1.1. Hepatoblastoma was the most common liver tumour accounting for 28 cases (71.8%), of which 25 cases (89.4%) were of pure epithelial type. The second most common primary tumour was epithelioid haemangioendothelioma with six cases (15.4%) with female preponderance, followed by two cases each of hepatocellular carcinoma and undifferentiated embryonal sarcoma and one case of hepatocellular adenoma. Serum AFP level was increased in hepatoblastoma and in hepatocellular carcinoma, normal in hepatocellular adenoma and embryonal sarcoma. Serum AFP level was increased in few cases of epithelioid haemangioendothelioma.

Conclusion: The spectrum of liver tumours in children is different from that in the adults. Hepatoblastoma is the most common paediatric liver tumour, followed by epithelioid haemangioendothelioma. Through better understanding of pathological diagnosis, refined surgical staging, newer and more effective radiological techniques and standardized multimodal therapies, a substantial number of children diagnosed with this highly malignant tumour can expect to survive the disease.


Epithelioid haemangioendothelioma, Hepatic tumour, Hepatoblastoma, Hepatocellular carcinoma

How to cite this article :

Esakki Muthuvel, Vimal Chander Chitra Srinivasan. A CLINICOPATHOLOGICAL STUDY OF PAEDIATRIC LIVER TUMOURS IN A TERTIARY CARE HOSPITAL. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Apr 27 ]; 11:EC50-EC53. Available from

DOI and Others

DOI: 10.7860/JCDR/2017/24223.9592

Date of Submission: Sep 17, 2016
Date of Peer Review: Oct 29, 2016
Date of Acceptance: Dec 08, 2016
Date of Publishing: Mar 01, 2017


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