Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : CC13 - CC16

Cortical Potentials Prior to Movement in Parkinsonís Disease

Ashlesh Laxman Patil, Sanjay Kumar Sood, Vinay Goyal, Kanwal Preet Kochhar

1. Senior Resident, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India. 2. Professor, Department of Physiology, RAK College of Medical Sciences (RAKMHSU), Ras Al Khaimah, United Arab Emirates. 3. Professor, Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. 4. Professor, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.

Correspondence Address :
Dr. Kanwal Preet Kochhar,
Professor, Department of Physiology, All India Institute of Medical Sciences,
New Delhi-110029, India.
E-mail: kpkochhar6@gmail.com

Abstract

Introduction: Recording cortical potentials prior to movement (bereitschaftspotentials, BP) offer a good non invasive method for studying activity of motor related cortices in Parkinsonís Disease (PD). Dopaminergic medications provide some symptomatic relief in advanced stages but they do not stop the progression of the disease. Assessing BP may be a good idea to see the response of anti PD drugs. It remains unclear whether the anti PD medications also improve cortical activity prior to movement even in advanced stages of the disease.

Aim: In this study we recorded scalp BP in patients with varying grades of severity to study the relationship between disease severity and various components of BP.

Materials and Methods: We successfully recorded BP at Cz, C3 and C4 sites during self-initiated 100 right wrist movements in 12 male patients with PD having severity Hoehn and Yahn (H &Y) scale 4 (PD3 group). These potentials were compared with age matched patients with H&Y scale 2 (PD1) and scale 3 (PD2) and also with age matched healthy controls.

Results: We found flatter waveforms with increasing severity of disease. Amplitude is first to be affected in mild severity as compared to controls (p=0.011); while with increasing severity early as well as late part of potentials is affected. Such changes are prominently seen at Cz site across the groups.

Conclusion: These findings imply that there is increasing defect in cortical activity during movement especially in supplementary motor area with increasing severity in PD in spite of dopaminergic medications. This dynamic nature of dysfunction in supplementary motor cortices must be taken in account while treating advanced cases using newer stimulation techniques.

Keywords

Bereitschaftspotentials, Hoehn & Yahn scale, Levodopa, Motor planning

How to cite this article :

Ashlesh Laxman Patil, Sanjay Kumar Sood, Vinay Goyal, Kanwal Preet Kochhar. CORTICAL POTENTIALS PRIOR TO MOVEMENT IN PARKINSONíS DISEASE. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Mar 29 ]; 11:CC13-CC16. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=CC13-CC16&id=9598

DOI and Others

DOI: 10.7860/JCDR/2017/25520.9598


Date of Submission: Dec 22, 2016
Date of Peer Review: Jan 19, 2017
Date of Acceptance: Jan 30, 2017
Date of Publishing: Mar 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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