Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Dr Mohan Z Mani

"Thank you very much for having published my article in record time.I would like to compliment you and your entire staff for your promptness, courtesy, and willingness to be customer friendly, which is quite unusual.I was given your reference by a colleague in pathology,and was able to directly phone your editorial office for clarifications.I would particularly like to thank the publication managers and the Assistant Editor who were following up my article. I would also like to thank you for adjusting the money I paid initially into payment for my modified article,and refunding the balance.
I wish all success to your journal and look forward to sending you any suitable similar article in future"



Dr Mohan Z Mani,
Professor & Head,
Department of Dermatolgy,
Believers Church Medical College,
Thiruvalla, Kerala
On Sep 2018




Prof. Somashekhar Nimbalkar

"Over the last few years, we have published our research regularly in Journal of Clinical and Diagnostic Research. Having published in more than 20 high impact journals over the last five years including several high impact ones and reviewing articles for even more journals across my fields of interest, we value our published work in JCDR for their high standards in publishing scientific articles. The ease of submission, the rapid reviews in under a month, the high quality of their reviewers and keen attention to the final process of proofs and publication, ensure that there are no mistakes in the final article. We have been asked clarifications on several occasions and have been happy to provide them and it exemplifies the commitment to quality of the team at JCDR."



Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
Ex-President - National Neonatology Forum Gujarat State Chapter
Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018




Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



Dr Kalyani R
Professor and Head
Department of Pathology
Sri Devaraj Urs Medical College
Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
On Sep 2018




Dr. Saumya Navit

"As a peer-reviewed journal, the Journal of Clinical and Diagnostic Research provides an opportunity to researchers, scientists and budding professionals to explore the developments in the field of medicine and dentistry and their varied specialities, thus extending our view on biological diversities of living species in relation to medicine.
‘Knowledge is treasure of a wise man.’ The free access of this journal provides an immense scope of learning for the both the old and the young in field of medicine and dentistry as well. The multidisciplinary nature of the journal makes it a better platform to absorb all that is being researched and developed. The publication process is systematic and professional. Online submission, publication and peer reviewing makes it a user-friendly journal.
As an experienced dentist and an academician, I proudly recommend this journal to the dental fraternity as a good quality open access platform for rapid communication of their cutting-edge research progress and discovery.
I wish JCDR a great success and I hope that journal will soar higher with the passing time."



Dr Saumya Navit
Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
Lucknow
On Sep 2018




Dr. Arunava Biswas

"My sincere attachment with JCDR as an author as well as reviewer is a learning experience . Their systematic approach in publication of article in various categories is really praiseworthy.
Their prompt and timely response to review's query and the manner in which they have set the reviewing process helps in extracting the best possible scientific writings for publication.
It's a honour and pride to be a part of the JCDR team. My very best wishes to JCDR and hope it will sparkle up above the sky as a high indexed journal in near future."



Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata




Dr. C.S. Ramesh Babu
" Journal of Clinical and Diagnostic Research (JCDR) is a multi-specialty medical and dental journal publishing high quality research articles in almost all branches of medicine. The quality of printing of figures and tables is excellent and comparable to any International journal. An added advantage is nominal publication charges and monthly issue of the journal and more chances of an article being accepted for publication. Moreover being a multi-specialty journal an article concerning a particular specialty has a wider reach of readers of other related specialties also. As an author and reviewer for several years I find this Journal most suitable and highly recommend this Journal."
Best regards,
C.S. Ramesh Babu,
Associate Professor of Anatomy,
Muzaffarnagar Medical College,
Muzaffarnagar.
On Aug 2018




Dr. Arundhathi. S
"Journal of Clinical and Diagnostic Research (JCDR) is a reputed peer reviewed journal and is constantly involved in publishing high quality research articles related to medicine. Its been a great pleasure to be associated with this esteemed journal as a reviewer and as an author for a couple of years. The editorial board consists of many dedicated and reputed experts as its members and they are doing an appreciable work in guiding budding researchers. JCDR is doing a commendable job in scientific research by promoting excellent quality research & review articles and case reports & series. The reviewers provide appropriate suggestions that improve the quality of articles. I strongly recommend my fraternity to encourage JCDR by contributing their valuable research work in this widely accepted, user friendly journal. I hope my collaboration with JCDR will continue for a long time".



Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Reviews
Year : 2023 | Month : September | Volume : 17 | Issue : 9 | Page : VE01 - VE06 Full Version

The Impact of the COVID-19 Pandemic on Mental Health Among the General Population: A Narrative Review


Published: September 1, 2023 | DOI: https://doi.org/10.7860/JCDR/2023/60409.18428
Chinmayee Arvind Ladole, Kedar S Takalkar

1. Undergraduate Student, Department of Neurology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, Maharashtra, India. 2. Associate Professor, Department of Neurology, Datta Meghe Institute of Medical Science, Wardha, Maharashtra, India.

Correspondence Address :
Chinmayee Arvind Ladole,
Undergraduate Student, Department of Neurology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha-442004, Maharashtra, India.
E-mail: ladolechinmayee17@gmail.com

Abstract

The Coronavirus Disease-2019 (COVID-19) has infected millions of people worldwide, resulting in a global burden for long-term care of sufferers. The impact of COVID-19 has affected the mental health of innumerable people. Emotional, psychological, and social well-being are all parts of our mental health, influencing our thoughts, emotions, and behaviours. Additionally, it affects how people respond to stress and make good decisions. For instance, depression raises the risk of a wide range of physical health issues, especially chronic illnesses like diabetes, heart disease, and stroke. The COVID-19 pandemic has infected millions worldwide, leaving a global burden for the long-term care of COVID-19 survivors. Therefore, it is imperative to study the short-term (post-COVID) and long-term effects of COVID-19, specifically as the local and systemic pathophysiological outcomes of other coronavirus-related diseases (such as Middle East Respiratory Syndrome - MERS and Severe Acute Respiratory Syndrome Coronavirus 2 - SARS-CoV-2) have been well-documented. Mental health was evaluated using four psychological measurement scales to assess fear of COVID-19, depression, general anxiety, and post-traumatic stress. The worldwide social and economic upheaval has resulted in the worst recession since the Great Depression. The Impact of Event Scale-Revised and the Depression, Anxiety, and Stress Scale can be used to evaluate the psychological impact and mental health status. The main themes include the biology of stress and the effect of infection on the brain. Adversity can cause anatomical and functional changes in the brain. Although cortisol, for example, can alter brain architecture, tolerable stress is mitigated by protective systems and interpersonal connections that promote adaptive coping. The risk of physical and mental illness, as well as cognitive decline, may increase due to toxic stress, which is often caused by prolonged activation. From a behavioural standpoint, it is essential to understand burnout, compassion fatigue, grief, and other psychological processes and strategies in the context of the COVID-19 pandemic. COVID-19 has adversely affected the mental states of people. The COVID-19 pandemic is associated with significantly high levels of psychological distress that meet the threshold for clinical relevance. Mitigating the harmful effects of COVID-19 on mental health is an international public health priority.

Keywords

Anxiety, Coronavirus disease-2019, Severe acute respiratory syndrome coronavirus 2, Stress

The group of odd pneumonia cases detected in Wuhan, China, in December 2019 were identified by the World Health Organisation (WHO) as cases of COVID-19 on February 11, 2020 (1). The SARS-CoV-2, a newly discovered coronavirus strain, shared 79% of its genetic makeup with the SARS-CoV-2 from the 2003 SARS outbreak (1). The WHO classified the outbreak as a worldwide pandemic on March 11, 2020 (1). The quickly evolving situation had a vital influence on people’s lives and several facets of the community, personal, and global economies. It is expected that the uncertainties and anxieties brought on by the coronavirus, including widespread lockdowns and an economic downturn, would raise suicide rates and the rates of mental diseases linked to suicide (2).

The COVID-19 outbreak is posing considerable challenges to healthcare systems and societies worldwide. While knowledge on the acute phase of the disease has rapidly expanded, little is known about the consequences of COVID-19 following clinical remission. Global mental health is now under unprecedented threat from the COVID-19 epidemic. Due to the immature developing stage, the anxiety of infection, staying at home, postponement of school, and larger-scale threats like global financial recessions and their effects, children and youths may be more susceptible to the effects on psychological well-being (3). Monitoring the cognitive decline in older people depends on understanding the longstanding impact of coronavirus disease. The present review aims to evaluate the mental condition and the rate of cognitive ageing in older individuals who have recovered from COVID-19. Between February 10 and April 10, 2020, three COVID-19 designated hospitals in Wuhan, China, discharged and resettled 1,539 COVID-19 patients over 60 (4). A total of 436 COVID-19 patients were ultimately chosen as controls. An Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) was developed to quantify longitudinal cognitive decline. A Chinese version of the Telephone Interview of Cognitive State-40 was used to assess current cognitive status. Mental evaluations were conducted six months after the patient’s release (4). Psychiatric co-morbidities, particularly genetic abnormalities and neurodevelopmental disorders like autism, have been observed in individuals due to COVID-19. Intellectual developmental issues are increasingly linked to behavioural and psychiatric characteristics (5).

The coronavirus had various consequences on people’s lives, including the loss of loved ones. After the coronavirus pandemic, a condition arose where people faced mental health problems. It contends that the brain is an organ of computation. As a result, a computational framework will be needed to comprehend the diseases that result from it. The post-COVID results in several depressive and anxiety disorders among people (6). A rapidly expanding area called psychiatry aims to improve the lives of individuals with mental illnesses by applying computational neuroscience and machine learning advancements. It includes both theory- and data-driven approaches. Here is a review of current developments in theory-driven research. The brain is an organ of computation. As a result, a computational framework will be needed to comprehend the diseases that result from it. The authors have explored the field’s general and unique issues and provided solutions (7).

Long-term consequences after SARS-CoV-2 infection are becoming an essential burden to societies and healthcare systems. Numerous persistent health issues that can continue for weeks, months, or years are considered post-COVID illnesses. As it affects COVID-19 survivors at all stages of disease severity and involves newer persons, offspring, and those not in hospitals, this sickness is poorly understood. Although there may not be a precise diagnosis of chronic COVID-19, fatigue and dyspnoea, which persist for months after acute COVID-19, are the most often reported indications. Other enduring signs may involve cognitive and mental dysfunction, joint and chest aches, palpitations, myalgia, impairment of the senses of smell and taste, cough, headache, Gastrointestinal (GIT) and heart problems (8).

The danger of neurological consequences from COVID-19 impairs patients’ ability to function and their quality of life regularly. The present challenges of the pandemic are the intuition of these illnesses, the rigorous control of heart metabolic changes and risk factors, and the operative and safe treatment of these conditions. Rehabilitation is complex for these patients. Only 10.8% of all participants had no symptoms after recovering from the sickness; however, many subjects experienced several symptoms and illnesses (9). Fatigue was the most reported symptom (72.8%); however, a small percentage of individuals also reported more severe presentations, such as cerebral infarction, kidney dysfunction, inflammation of heart muscles, and pulmonary fibrosis (9). The severity of the condition was associated with the presence of additional comorbidities. Additionally, the intensity of post-COVID-19 symptoms was related to the severity of COVID-19 (10).

Various studies have been conducted on the connection between COVID-19 and mental health, mainly anxiety and depression in the overall population, and have been published since the development of COVID-19. Depression is a crippling condition that impairs people’s level of biopsychosocial functioning across all age groups (10).

In children: A small but growing number of people have long-lasting physical and mental health effects from SARS-CoV-2 infection. Although the incidence and severity of these indications in children and teenagers are not yet recognised, there seem to be a variety of onset patterns involving the persistence of acute phase symptoms, postviral symptoms like Chronic Fatigue Syndrome (CFS), pulmonary and cardiovascular problems, and cognitive problems (11). Possible symptoms include increased breathing effort, exhaustion, arthralgia, sleeplessness, decreased routine activities and mobility, and mood changes (11).

In adolescence: 44.8% of children and adolescents complained of extended COVID-19. Twelve people (21%) reported feeling fatigued, 7 (12%) reported having trouble breathing while exercising, 6 (10%) reported feeling weak, and 5 (9%) reported having difficulty walking (12). Long COVID-19 was significantly correlated with being older, experiencing muscular distress upon arrival, and being admitted to the Critical Care Unit. In children and teens, Long COVID-19 is a common condition. The scientific community should research the pathophysiology of prolonged COVID-19 to ensure that these patients receive proper medical attention for their ailment (12).

For adults aged under 50 years: Older individuals faced various conditions as post-COVID-19 effects, such as affected pulmonary function, irregular Computed Tomography (CT) results involving pulmonary fibrosis (39-83%), an indication of myocarditis (3-4%), increased occurrence of mental diagnoses (5.8% versus 4.4%), persistent tiredness (39-73% of assessed persons), breathing difficulty (39-74%), a decline in quality of life (44-69%), and persistent fatigue (13). After recovery, COVID-19 has intermediate and long-term impacts on several organ systems. These consequences 2include persistent fatigue, reduced lung function, and inflammation of the heart. Thorough follow-up after COVID-19 is recommended to evaluate and minimise potential organ injury and preserve the quality of life (13).

In old age: The prevalence of extended COVID-19 varied from 4.7% to 80%, and the most common signs and symptoms were coughing and sputum production, exhaustion, and chest discomfort (89%) (14). Three to 24 weeks following the acute phase or hospital release were utilised as the temporal criterion to identify Long COVID-19. Possible related risk factors were advanced age and acute oxygen supplementation (15). The most common clinical symptoms associated with the illness were cough, tiredness, dyspnoea, and chest discomfort. These systematic review findings indicate a pressing need to comprehend this new, complex medical condition (15).

Mental Illness

In significant public health emergencies, more than half of the interviewees experience mental health issues and urgently require psychological support (16). COVID-19 is no exception. The abrupt onset of this illness acts as a stressor, significantly impacting the ordinary life of the public and their mental health. There are numerous potential causes for this condition, including the spread of several viral diseases, fear among the general public, stringent public health measures limiting personal freedoms, increasing economic pressure, the challenging task of healthcare professionals, delayed work and school start, and the overwhelming epidemic news on the internet. Any medical conditions (such as depression, schizophrenia, obsessive-compulsive disorder, or panic disorder) are characterised primarily by sufficient disorganisation of character, mind, or emotions to impair normal psychological functioning and lead to noticeable disability. These conditions often disrupt everyday thinking, emotions, mood, behaviour, interpersonal interactions, and routine functioning. Depression, anxiety disorders, schizophrenia, eating disorders, and compulsive behaviours are common issues that may affect individuals who have recovered from cancer (16).

During development: Some mental illnesses have been linked to damaged neural connections or nerve cell circuits in specific brain regions. Neurotransmitters are molecules that mediate communication between nerve cells within specific brain circuits. “Tweaking” these molecules through medication, psychotherapy, or other medical methods can help brain circuits function more efficiently. Additionally, several mental diseases have been associated with defects or harm in certain brain regions. The risk of morbidity and mortality increases in individuals with Opioid Use Disorder (OUD), where mental problems can be observed (17). It is crucial to address these co-occurring problems to improve treatment and health outcomes. Limited recent studies exist on the frequency of co-occurring disorders, the demographic factors associated with co-occurring disorders, and the utilisation of mental health and drug use therapy among OUD patients (17). This hinders the development of well-resourced and focused treatments and policies (17).

Depression

The most prevalent mental condition in the world and one of the leading causes of disability, as assessed by years lived with the disease, is depression, commonly known as Major Depressive Disorder (MDD). According to the World Health Organisation (WHO), over 264 million individuals are currently battling with MDD (18). Despite psychiatry’s ongoing search for valuable biomarkers of MDD, which could enable quicker detection of the disease, implementation of treatment, and more objective monitoring of its effectiveness, the diagnosis of MDD is primarily based on clinical symptoms and scales. They recommend assessing the psychiatry of COVID-19 survivors and conducting further research on inflammatory biomarkers to diagnose and treat emerging mental conditions. This is due to the troubling effects of COVID-19 infection on psychological health, current understanding of inflammation in psychiatry, and the recent observation that worse inflammation results in worse depression (18).

Regarding diagnostic measures, while anxious depression (comorbid anxiety and depression) is a relatively frequent illness, depression has been classified as a separate entity. It is well established that anxious depression differs neurobiologically from non-anxious depression (19).

Anxiety Disorder

Due to the widespread nature of COVID-19, anxiety problems have become increasingly common among the population. The emotional reactions triggered by the disease, its severe side effects, and the implemented lockdown to protect against COVID-19 have resulted in limited social interactions. As a consequence, people have turned to increased internet use as a poor coping mechanism, leading to feelings of loneliness. Generalised Anxiety Disorder (GAD) is a prevalent and highly debilitating psychological health condition. However, there is still much to learn about relevant biomarkers and diagnosis, which becomes more challenging due to GAD’s frequent overlap with affective and anxiety disorders (20). Childhood and adolescence are critical developmental periods for anxiety symptoms and syndromes, ranging from mild to severe anxiety disorders. This article reviews epidemiological data on the prevalence, incidence, course, and risk factors (21). In some cases, chronic schizophrenia impairs several cognitive processes such as memory, cognition, perception, and volition. The link between schizophrenia and melatonin has been established since the early 20th century (22). The accurate diagnosis of schizophrenia and the selection of effective therapies remain challenging due to unreliable diagnostics (23).

Post-COVID Effects

Recent investigations examining the long-lasting consequences of COVID-19 on patients have led to the definition of long-COVID-19. This refers to the ongoing symptom burden experienced by COVID-19 patients, particularly those who were part of the pandemic’s initial wave. After being discharged from a significant teaching hospital trust, every patient with COVID-19 pneumonia received follow-up care. During the follow-up, 86% of patients reported experiencing at least one lingering symptom, while no patients had ongoing radiographic abnormalities (24). The severity of acute COVID-19 illness did not correlate with the presence of symptoms during the follow-up period. The persistent symptoms include anxiety, fatigue, and muscle pain, which were predominantly observed in women (24). Long-lasting symptoms are commonly found in individuals who have had COVID-19. The authors argue that the phenomenon of long-COVID may not be solely attributable to the impact of SARS-CoV-2, and that the biopsychosocial effects of COVID-19 may have a more significant role in its development (24). Utilising neuroscience to mitigate the effects of physiological and psychological stress and prevent long-term damage would be a significant endeavor. In this context, neuroscience supports the use of evidence in policymaking. The biology of stress, as well as the impact of infection on the brain, are prominent issues to consider.

Adversity can cause anatomical and functional changes in the brain, which is the organ responsible for stress and adaptation, as well as behavioural, neuroendocrine, autonomic, and immunologic responses to adverse events. While cortisol, for example, can alter brain structure, protective systems and interpersonal connections that promote adaptive coping mask tolerable stress. Prolonged activation, leading to toxic stress, increases the risk of physical and mental illness as well as cognitive decline. From a behavioural perspective, it is crucial to understand burnout, compassion fatigue, grief, and other psychological processes and strategies in the context of the COVID-19 pandemic, particularly among healthcare and frontline workers. The SARS-CoV-2 infection that causes COVID-19 has resulted in various challenging and difficult-to-treat health issues. One of these challenges is post-COVID-19 syndrome, which has become increasingly prevalent as the epidemic progresses (25).

Despite the remission of acute infection, COVID-19 is associated with clinically severe symptoms, known as post-COVID-19 condition. The most prevalent and debilitating symptom of post-COVID-19 condition is fatigue, followed by cognitive impairment (26). Along with fever, loss of taste and smell, and cough, persistent fatigue, cognitive decline, dyspnoea, or discomfort are commonly observed in individuals with COVID-19. This collection of long-lasting effects is referred to as post-COVID-19 syndrome or protracted COVID-19 (27).

While COVID-19 brain involvement typically occurs during the acute phase of infection, neurological and psychological consequences are also common during the post-COVID-19 phase. Specifically, Post-COVID-19 Neurological Syndrome (PCNS) is an increasingly recognised side effect of COVID-19. Therefore, cognitive and psychiatric functions need to be closely monitored in COVID-19 patients who survive beyond the acute phase (27). A wide range of symptoms have been reported, including muscle discomfort, vertigo, migraines, fatigue, anosmia, amnestic dysfunction, ataxia, and sleep problems. These findings have led to the emergence of post-COVID syndrome, also known as long-COVID, which is characterised by a prolonged course of various physical and neuropsychiatric symptoms lasting for more than 12 weeks without a clear explanation. However, it is acknowledged that there is minimal correlation between the severity of the acute illness and the likelihood of developing long-COVID-19 (24). Currently, it is unknown who is at a higher risk of developing long-COVID (24).

A survey revealed that 60% of respondents reported worsened mental health due to the pandemic. Younger age, difficulty accessing mental health treatments, lower income, COVID-19-related economic impact, stress related to COVID-19, lack of sleep, and increased alcohol/drug use were all associated with increased feelings of sadness, anxiety, and decreased well-being (28). Having social support from friends, family, and services was linked to better mental and physical health. Individuals with a history of anxiety, depression, Post-Traumatic Stress Disorder (PTSD), or an eating disorder were more likely than those without such a history to report worsened mental health during the pandemic. Feelings of confusion, panic, insecurity, and sadness were prevalent among different groups of people (28). Evidence-based psychological therapies that aim to reduce acute stress and prevent the development of psychological disorders in this population are needed, as distress symptoms are expected to persist long-term and have a systemic impact on healthcare systems (29). The COVID-19 pandemic has had a detrimental effect on people’s mental health worldwide, leading to prevalent symptoms of PTSD, anxiety, and depression. This can result in stress, depression, headaches, and anxiety, leading to impaired brain function and, if not addressed promptly, further complications.

Effect of Stress

Neurons are cells that receive sensory input and use neurotransmitters to transmit information to other cells. They are considered the fundamental units of the nervous system. Interestingly, the term ‘neuron’ did not exist until 1891 (30). By the mid-nineteenth century, scientists had discovered that every living organism was composed of distinct “cells,” with the nervous system being the only exception (30). The development of the electron microscope in the 20th century later revealed that neurons communicate with each other through electrical and chemical synapses, indicating the presence of voltage-gated ion channels on dendrites and the propagation of action potentials from the cell body, which plays a crucial role in nearly all physiological processes in living systems (30).

The long-term consequences for survivors of severe illness since the emergence of the novel coronavirus in China are still unclear (31). Researchers have theorised that COVID-19 may lead to post-viral sequelae, which can be permanent and debilitating, as the global pandemic continues to spread and result in numerous fatalities and morbidities (31). One well-known side effect of several viruses is Chronic Fatigue Syndrome (CFS), which presents as prolonged relapses of fatigue, cognitive impairment, depression, and other symptoms following even mild exertion. Previous studies have shown that many survivors of the SARS-CoV-2 pandemic experienced symptoms similar to CFS. However, since there is no widely accepted diagnostic procedure for CFS, it is necessary to first rule out any conditions with comparable symptoms (31).

Many professionals in the mental health and psychology fields believe that the effects of the coronavirus pandemic may not be as apparent now as they will be once the pandemic phase has passed (32). This is influenced by the current tendency of many individuals to normalise and adapt to their surroundings. According to a study, numerous academics, the full extent and impact of societal trauma will not be fully understood until the epidemic is over. Many also propose the existence of post-pandemic stress disorder (32). Since the beginning of the 21st century, pandemics have increased in frequency and complexity. PTSD is a significant public health concern following pandemics. Through a comprehensive study and meta-analysis, the authors aimed to accurately estimate the global prevalence of PTSD following major pandemics, as well as any associated risk factors (33).

Anxiety

Some people have intense tension and worry about passing away or getting sick. They report considerable anxiety, annoyance, uncertainty, sleeplessness, and stress due to the social isolation and confinement they have experienced. Other risk factors for mental health illnesses include excessive social media usage, low socioeconomic position, poor resilience, and a lack of social support (34). Even though many lockdowns and restrictions have been lifted, and up to 62% of Americans have received all recommended vaccinations, many people say they continue to experience tremendous terror in the months after recovering from COVID-19 sickness (34). Anxiety is one of the more persistent indications of post-COVID condition, also called long-COVID-19. This is a recently diagnosed condition. According to research, mainly women experience mental health issues (such as anxiety) after beating the illness (34). According to other research, that number is higher, hovering around the 50% range. Other mental health problems, such as GAD, Obsessive-Compulsive Disorder (OCD), and PTSD, share symptoms with post-COVID-19 anxiety. Severe depression and health anxiety can also occur (34). Anxiety is a state of worry that frequently manifests as an emotional response to instinctively perceived dangerous circumstances. This sensation typically goes hand in hand with fatigue, irritability, tiredness, and attention deficit. Long-term anxiety affects the brain’s chemistry and causes a spike in stress hormones, making dizziness, headaches, and depression symptoms worse or more frequent (34).

Social Determinants and Society

The reality is that structural inequities restrict the range of options disadvantaged individuals have for realising their full potential in health, notwithstanding ongoing arguments concerning the extent to which individual actions contribute to health inequalities. For instance, according to an estimation from the US Centre for Disease Control and Prevention (CDC), Black people have died from COVID-19 at a rate more than double that of white people. Racial differences in COVID-19 cases and deaths have been attributed to several pathways, including genetic susceptibility, medical discrimination in testing and treatments, and health disparities. Black populations predominantly experience cardiovascular disease and asthma, two major risk factors for COVID-19 (35). The average time after diagnosis was 8.1 (3.2) months, with 83.0% of the 230 responders (6.3% response rate) having a history of COVID-19 hospitalisation (35). On average, the age was 43.1 (14.3) years. Anxiety was the domain with the lowest Health-Related Quality of Life (HRQoL) scores across the board, with an average Patient-Reported Outcomes Measurement Information System (PROMIS)-Preference score (PROPr) health utility of 0.36 (0.25). All domain scores were identical across racial groups except for cognitive function skills, which had lower scores among Latinos (35). Interpersonal conflict was connected to lower health utility and worse outcomes in six of the eight PROMIS domains. In contrast, financial worries were linked to lower health utility and worse results in all eight domains (anxiety, depression, fatigue, sleep trouble, social function, and pain interference). After controlling for other factors, Latino ethnicity was only linked to lower scores in one PROMIS domain (35).

Participants’ health, social well-being, and food security were all affected differently by the COVID-19 pandemic and response efforts. The COVID-19 pandemic had a limited impact on about 40% of the participants (36). On the other hand, individuals who were significantly affected experienced the emergence of new mental health issues such as anxiety and stress, as well as the worsening of pre-existing psychological conditions including depression, posttraumatic stress disorder, and OCD (36). Along with limited access to free activities and restricted food supplies, they also struggled with feelings of isolation and loneliness. The pandemic also resulted in disparities in access to healthcare services and continuity of treatment for unrelated health concerns. Overall, participants who had access to phones, the internet, and media devices found it easier to follow COVID-19 public health measures and obtain reliable information about preventive measures (36). In conclusion, individuals experiencing homelessness and mental illnesses, who require social and housing services, were impacted in various ways by the widespread COVID-19 and associated response measures, in terms of their health, social well-being, free time, and food security (36).

Government-imposed controls during the COVID-19 pandemic likely contributed to its prevention, but they may have also led to prolonged periods of sedentary behaviour across all societal groups. This study analysed the sedentary behaviour of Thai individuals before and during the COVID-19 epidemic to investigate this phenomenon (37). The analysis utilised the Surveillance on Physical Activity (SPA) datasets for 2019 and 2020, comprising a total of 5,379 individuals (SPA2019) and 6,531 individuals (SPA2020) aged 18-64 years who were connected to the internet (37).

There is a genuine risk of developing an “after the pandemic double burden of illness,” which would add the stress of managing severe COVID-19-related effects on the healthcare system to the existing burden of long-term ailments or chronic non-communicable diseases already present in industrialised nations. Neglecting pre-existing medical issues may lead to a post-pandemic health crisis. The potential negative effects of short-term health crises on long-term community health are highlighted by an expanding body of research from previous epidemics and health emergencies. If the severe disruptions to standard healthcare systems and society are not well managed, they may result in higher morbidity and mortality in the long run. This argument outlines the data supporting the care of long-term conditions during and after health crises to mitigate the short-term and long-term impact of COVID-19 on public health (38).

Treatment

There are currently few treatment options available since the mechanisms of extended COVID-19 are not well understood. However, there are some simple methods that can help reduce stress on mental health. If you experience stress or depression, it is important to consult a physician. Follow the medication prescribed by the physician. Additionally, remember to drink enough water and inhale steam. If these symptoms persist, speak with your doctor. If you have trouble falling asleep, consider sleeping on your right or left side rather than your back, as it may facilitate restful sleep (39).

Psychotherapeutic treatments include psychotherapy and behaviour therapy techniques such as relaxation training or exposure therapy, as well as hypnotherapy. The most commonly used drugs are antidepressants like selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors. It is important to maintain your exercise routine, which can include exercises for your chest and breathing like pranayama, self-awake pruning, yoga, and meditation. Maintaining a healthy diet is essential, including meals that provide energy such as cereals, foods that build muscle such as pulses, dairy products, and animal foods, as well as foods that strengthen your immune system such as those high in vitamins and minerals (19).

Conclusion

During the pandemic, many lives were lost, and thousands of people lost their loved ones. Such a situation has led to increased stress and anxiety, making life more threatening for people. The widespread of COVID-19, a significant virus epidemic in the 21st century, has posed unprecedented risks to mental health worldwide. It is important that, at this moment, no one should perpetuate stigma. Similar to other chronic medical illnesses, severe mental illness can have fatal consequences and lead to other emergencies in the future if regular treatment is not provided. This risk can be reduced through the use of telepsychiatry, psychosocial therapy delivered through technology, changes to regulations to ensure continuity of care for acute treatments, and the protection of treatments for vulnerable groups. By maintaining physical distance and connections, clinicians and patients can navigate through challenging times. To avoid stress and anxiety, it is important to consult a physician, maintain a healthy diet, and follow proper yoga and medication practices to prevent further consequences.

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DOI and Others

DOI: 10.7860/JCDR/2023/60409.18428

Date of Submission: Sep 24, 2022
Date of Peer Review: Nov 10, 2022
Date of Acceptance: Apr 19, 2023
Date of Publishing: Sep 01, 2023

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. NA

PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Sep 27, 2023
• Manual Googling: Nov 15, 2023
• iThenticate Software: Apr 14, 2023 (12%)

ETYMOLOGY: Author Origin

EMENDATIONS: 6

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