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Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."
Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011
Dr. Shankar P.R.
"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."
Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011 Anuradha
Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.
Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020
Case report
Full Version
A Rare Case of Aerococcus viridans Meningitis in a Patient with Trigeminal Nerve Schwannoma
Correspondence Address :
Dr. Chinmoy Sahu,
Additional Professor, Department of Microbiology, C-Block, 2nd Floor, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India.
E-mail: csahu78@rediffmail.com
The genus Aerococcus spp. comprise microaerophilic, catalase-negative, Gram-positive cocci that show alpha-haemolytic growth on blood agar. They have a tendency to divide on two planes at a 90° angle, and rapid multiplication leads to the formation of Gram-positive cocci in tetrads and irregular clusters. Aerococcus spp. are capable of causing invasive and fatal systemic illnesses, such as endocarditis, bactereamia, arthritis, and meningitis. Due to evolving diagnostic tools, it is now identified as a pathogen in a variety of disorders instead of being considered a contaminant. Most isolates are susceptible to penicillins, but there is increasing resistance to cephalosporins, ciprofloxacin, cotrimoxazole, clindamycin, vancomycin, and tetracycline. Here, authors present a rare case of Aerococcus viridans meningitis in a patient who underwent surgical excision of a left trigeminal Schwannoma, along with the drug susceptibility pattern resistant to most first-line antibiotics used against isolates from Streptococci spp., except doxycycline.
Bacteraemia, Drug susceptibility pattern, Endocarditis, Gram-positive cocci, Penicillins
A 26-year-old woman presented to the Emergency Department with the chief complaint of holocranial headache for the past two years, vomiting with a headache, and loss of sensation over the left half of the face for the past three months. She was sent for contrast-enhanced Magnetic Resonance Imaging (MRI), which suggested a single well-defined lesion present at the left Meckel’s cave measuring 4×2 cm. The lesion appeared hypointense on T1 and hyperintense on T2 (as shown in (Table/Fig 1)), extending into the middle cranial fossa from the posterior cranial fossa and causing mild compression of the midbrain. This was suggestive of a left trigeminal nerve Schwannoma, which was confirmed by histopathological examination (Table/Fig 2). The examination showed haemosiderin-laden macrophages called Verocay bodies, which are pathognomic of Schwannomas. She was referred to the Department of Neurosurgery at Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, and advised to undergo resection of the trigeminal nerve lesion. The surgical procedure involved a left temporal craniotomy, zygoma lowering, middle cranial fossa extradural approach, and gross total excision of the tumour under general anaesthesia. After the surgery, a subcutaneous drain was placed and closed with sutures and dressing due to a cerebrospinal fluid (CSF) leak. Two days following the surgery, she developed a high-grade fever of 103°F and experienced two episodes of seizures. Meningitis She was suspected, and a CSF sample was sent for body fluid analysis.
The analysis revealed a lymphocyte count of 60% and a polymorph count of 40%. CSF glucose was low (32 mg/dL), total cell count was 103 cells/cubic mm, and CSF protein was 256 mg/dL. These e findings indicated bacterial meningitis (1). A CSF sample was then sent for routine aerobic bacterial culture and microscopy to the Bacteriology section in the Department of Microbiology at Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. On wet mount, the sample showed plenty of red blood cells, a few pus cells, and a few non-motile cocci.Gram’s stained smear revealed a few pus cells and a few Gram-positive cocci (Table/Fig 3). The CSF samplewas subcultured on MacConkey’s agar and blood agar, and incubated at 37°C. After 16 to 18 hours ofincubation, pinpoint colonies with alpha-haemolysis were observed on blood agar (Table/Fig 3). We advised arepeat sample after changing the external drain and collecting bag to confirm the pathogenic nature of themicroorganism and exclude the presence of colonising flora in the drain (2). On the repeat sample after changing the drain, the same isolate was confirmed using Matrix Assisted Laser Desorption/Ionisation-Time Of Flight-Mass Spectrometry Assay (MALDI-TOFMS) (3). Further antibiotic sensitivity testing was performed usingthe Kirby Bauer disc-diffusion method following CLSI 2019 guidelines (4). The tested antibiotics against theisolate were ampicillin, doxycycline, gentamicin, levofloxacin, linezolid, minocycline, ampicillin-sulbactam, teicoplanin, and vancomycin. The isolate was found susceptible to doxycycline, minocycline, and linezolid. Although amoxicillin/clavulanic acid had been started after the blood sample was sent, it failed to alleviate the patient’s symptoms of the patient. The patient was shifted from amoxicillin/clavulanic acid to doxycycline. After three days of antimicrobial treatment, the patient became afebrile, and no seizure episodes were noted. The drain was removed a week after the procedure, and the further hospital stay was uneventful. She was maintained on doxycycline and asked to follow-up after two weeks. Unfortunately, as she was lost to follow-up, her progress could not be traced further.
The Aerococcus genus comprises microaerophilic, catalase-negative, Gram-positive cocci that show alpha haemolytic colonies on blood agar. They have a tendency to divide on two planes at a 90° angle, and rapid multiplication leads to the formation of Gram-positive cocci in tetrads and irregular clusters (5). The most common species of Aerococcus identified is Aerococcus urinae, followed by Aerococcus sanguinocola, Aerococcus viridans, Aerococcus christensenii, Aerococcus suis, and others [6-10]. It is capable of causing invasive and fatal systemic illnesses such as endocarditis, bacteraemia, arthritis, and meningitis. With the use of evolving diagnostic tools like MALDI-TOF-MS and Vitek-2, Aerococcus viridans is now recognised as a pathogen in a variety of disorders instead of being considered a contaminant (11). We present a rare case of Aerococcus viridans meningitis in a patient who underwent surgical excision of a left trigeminal Schwannoma.
Due to the scarcity of reported cases of Aerococcus viridans meningitis in the literature, we report the fourth case of Aerococcus viridans meningitis from India. A rare case of urinary tract infection caused by Aerococcus viridans has been previously reported from India (12). Nathavitharana KA et al. reported a series of cases of acute meningitis caused by Aerococcus viridans in three children in 1983, with a reported mortality rate of 33.33% (1/3, 33.33%) (13). Another study by Chandran S et al., reported a case of aseptic meningitis caused by Aerococcus viridans when CSF fluid samples were assessed using FilmArray Meningitis (14).
Most Aerococcus isolates were found to be susceptible to penicillins, with increased Minimum Inhibitory Concentration (MIC) to cephalosporins, ciprofloxacin, cotrimoxazole, clindamycin, vancomycin, and tetracycline (12). Interestingly, the isolate in this case was found to be susceptible to doxycycline, minocycline, and linezolid. A similar susceptibility to tetracyclines was observed in our study, as reported by Mohan B et al. (12). The use of MALDI-TOF-MS brought this underreported microorganism to light in duplicate samples from the same patient, along with identical drug susceptibility in our case. This study emphasises the significance of MALDI TOF-MS in identifying of rare and underreported isolates from the CSF, and the need for specific CLSI/EUCAST antimicrobial susceptibility guidelines for these isolates.
This study emphasises the importance of MALDI-TOF-MS in the identification of this isolate, which can easily be misidentified as alpha-haemolytic streptococci. We identified the fourth case of Aerococcus viridans meningitis in India in a postoperative case of trigeminal Schwannoma and it represents the sixth case of Aerococcus viridans meningitis worldwide. Present study also provides clinicians with insight into the drug susceptibility pattern of this rarely isolated bacterium.
DOI: 10.7860/JCDR/2023/63542.18183
Date of Submission: Feb 16, 2023
Date of Peer Review: Apr 19, 2023
Date of Acceptance: May 24, 2023
Date of Publishing: Jul 01, 2023
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. No
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Mar 13, 2023
• Manual Googling: Apr 18, 2023
• iThenticate Software: May 22, 2023 (10%)
ETYMOLOGY: Author Origin
EMENDATIONS: 5
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase
- EBSCOhost
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)
- www.omnimedicalsearch.com