Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 43602

Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : SE01 - SE05

Autism Spectrum Disorders-Aetiopathogenesis

Babu George, ML Leena, MKC Nair

1. Director, Child Development Centre, Thiruvananthapuram, Kerala, India. 2. Senior Research Coordinator, Child Development Centre, Thiruvananthapuram, Kerala, India. 3. Professor Emeritus, Developmental, Behavioural and Adolescent Paediatrics, Child Development Centre, Thiruvananthapuram, Kerala, India.

Correspondence Address :
Dr. Babu George,
Director, Child Development Centre, Thiruvananthapuram-695011, Kerala, India.


Autism Spectrum Disorders (ASD) are characterised by a range of clinical features that can vary from individual to individual in both degree of severity and variability of the clinical presentation. The aetiology or causation of ASD has been a widely debated issue for several decades; however, the exact cause of autism is still unknown. Research has suggested that ASD may be caused by genetic and/or environmental factors. Among those, children with low genetic susceptibility, some maternal and obstetric factors have an independent role in autism aetiology, whereas among genetically susceptible children, these factors appear to play a lesser role. It was observed that there is an increased risk of ASD due to: (i) advanced maternal age; (ii) advanced paternal age; (iii) duration of gestation; (iv) intrapartum hypoxia; and (v) birth weight. Recent evidence also suggests potential links of immune dysfunction, dietary, metabolic and gastrointestinal factors.


Environmental factors, Genetic factors

How to cite this article :

Babu George, ML Leena, MKC Nair. AUTISM SPECTRUM DISORDERS-AETIOPATHOGENESIS. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jul 17 ]; 12:SE01-SE05. Available from

DOI and Others

DOI: 10.7860/JCDR/2018/36431.11751

Date of Submission: Mar 15, 2018
Date of Peer Review: Apr 03, 2018
Date of Acceptance: May 30, 2018
Date of Publishing: Jul 01, 2018


JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)