Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 22757

Original article / research
Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : SC01 - SC06

A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India

Padmanabhan P Athira, Ozhiparambil A Jagan, Padma Umadevi, Komaravolu Pragnatha, P Menon Veena

1. Student, Department of Pharmacology, Amrita School of Pharmacy, Amrita University, Kochi, Kerala, India. 2. Lecturer, Department of Clinical Virology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India. 3. Associate Professor, Department of Pharmacology, Amrita School of Pharmacy, Amrita University, Kochi, Kerala, India. 4. Pediatric Consultant, Department of Pediatric, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India. 5. Professor, Department of Clinical Virology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.

Correspondence Address :
Dr. P Menon Veena,
Professor, Department of Clinical Virology, Amrita Institute of Medical Sciences, AIMS Ponekkara, Kochi-682041, Kerala, India.
E-mail: vpmenon26@gmail.com

Abstract

Introduction: Dengue is an important arthropod-borne viral infection in humans and is the second most important reemerging tropical disease. Children are particularly at risk of developing severe dengue and clinically identifying such cases are often a challenge.

Aim: To characterise the clinical and laboratory risk factors of dengue fever and its severity in children.

Materials and Methods: Retrospective evaluation of demographics, clinical, laboratory findings and outcome of suspected dengue fever in children admitted to the hospital between Jan 2015 - Feb 2017 was performed to identify risk factors of dengue fever and its severity.

Results: During the study period, a total of 211 children were clinically suspected on the admission as dengue fever, 34 of these were serologically confirmed dengue positive. A 74% (27/34) of these were primary dengue infections. The mean age of the dengue cohort was 7.6 years (s.d. 4.8) with 59% (20/34) being boys. Based on 2009 WHO clinical criteria, 16 were identified as Dengue with warning Signs (DS), 7 as Dengue Without warning Signs (DWS) while 11 were identified as Severe Dengue (SD). Some of the frequently observed clinical features were fever (31/34), headache (5/34), thrombocytopenia (9/34), leukopenia (4/34) and rash (5/34). The mean WBC in children with severe dengue was 7.9 % (s.d.5.0) with elevated monocytes 12.2 % (s.d.3.5) compared to 11.3% (s.d.5.8) and 6.6% (s.d.2.0) in children with DS and DWS respectively. Transaminitis was more frequently observed in severe dengue.

Conclusion: Clinical and laboratory parameters of acute febrile illness in children can act as early prognosticators of dengue fever and its severity.

Keywords

Arthropod, Flavivirus, Fever, Haemoconcentration, Thrombocytopenia

How to cite this article :

Padmanabhan P Athira, Ozhiparambil A Jagan, Padma Umadevi, Komaravolu Pragnatha, P Menon Veena. A RETROSPECTIVE STUDY OF PAEDIATRIC DENGUE CASES IN A TERTIARY CARE HOSPITAL IN SOUTHERN INDIA. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jul 16 ]; 12:SC01-SC06. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=July&volume=12&issue=7&page=SC01-SC06&id=11756

DOI and Others

DOI: 10.7860/JCDR/2018/34710.11756

Date of Submission: Nov 13, 2017
Date of Peer Review: Feb 07, 2018
Date of Acceptance: Mar 31, 2018
Date of Publishing: Jul 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: NONE.

JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • SCOPUS
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)
  • www.omnimedicalsearch.com