Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : BE01 - BE05

Nitric Oxide: Itís Role in Immunity

Shailaza Shreshtha, Preeti Sharma, Pradeep Kumar, Rachna Sharma, SP Singh

1. Research Scholar, Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India. 2. Associate Professor, Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India. 3. Professor, Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India. 4. Lecturer, Department of Biochemistry, TSM Medical College and Hospital, Lucknow, Uttar Pradesh, India. 5. Professor, Department of Biochemistry, Hind Medical College and Hospital, Lucknow, Uttar Pradesh, India.

Correspondence Address :
Dr. Preeti Sharma,
Associate Professor, Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
E-mail: prcdri2003@yahoo.co.in

Abstract

Nitric Oxide (NO), a lipophilic gas synthesised by the enzyme Nitric Oxide Synthase (NOS) from the substrate arginine, is an important biomolecule that mediates cellular signaling. It has a wide spectrum of biological functions including immunomodulation, inflammation, microbial and tumour eradication. Cells of the immune system such as macrophages on activation by cytokines and microbial antigens eradicate a number of microbes or parasites as well as tumour cells by releasing a number of effector molecules which also includes NO. However, this versatile molecule is shown to have dual roles. In lower concentration, this is beneficial and regulates the physiological processes in the body whereas at higher concentrations it is harmful to not only the microbes or tumor cells but can produce undesirable effects on the host cells too. This suggests that NO has both protective and toxic roles that occur parallel in the body depending upon cellular microenvironment. Therefore, it is very essential to have the knowledge of the physiological processes involved in signaling cascades of NO since it might have novel clinical applications when therapeutic potential of NOS inhibitors and NO donors are to be considered.

Keywords

Macrophages, Microbes, Nitric oxide synthase, Tumour cells

How to cite this article :

Shailaza Shreshtha, Preeti Sharma, Pradeep Kumar, Rachna Sharma, SP Singh. NITRIC OXIDE: ITíS ROLE IN IMMUNITY. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jul 17 ]; 12:BE01-BE05. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=July&volume=12&issue=7&page=BE01-BE05&id=11764

DOI and Others

DOI: 10.7860/JCDR/2018/31817.11764

Date of Submission: Jul 22, 2017
Date of Peer Review: Oct 05, 2017
Date of Acceptance: Feb 01, 2018
Date of Publishing: Jul 01, 2018


Financial Or Other cOmPeting intereStS: None.

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