Recurrent Aphthous Stomatitis: An Assessment of Antioxidant Levels in Plasma and SalivaCorrespondence Address :
Dr. J S Jesija,
Assistant Professor, Department of Dental and Oral Surgery, Christian Medical College, Vellore-632004, Tamil Nadu, India.
Introduction: Recurrent Aphthous Stomatitis (RAS) is a common oral mucosal disorder that affects 20% of the population worldwide. Factors such as trauma, stress, genetic, hypersensitivity, nutrition, immune disturbance, and hormonal imbalance may disturb the oxidant and antioxidant balance of an organism, and precipitate RAS, but the relationships are poorly understood.
Aim: The purpose of this study was to evaluate the antioxidant status in plasma and saliva of patients with RAS.
Materials and Methods: Forty patients with RAS and forty healthy individuals were included in the study. The levels of antioxidants such as Superoxide Dismutase (SOD), Glutathione Peroxidase (GSHPx) Catalase (CAT) and Uric Acid (UA) were measured in plasma and saliva. Statistical analysis was performed to compare the two groups using independent t-test and ANOVA.
Results: Decreased SOD levels were observed in plasma amongst RAS patients (p < 0.03) whereas, increased levels were observed in their saliva (p < 0.001) compared to the control group. A significant difference (p < 0.001) was noticed in GSHPx levels: RAS patients exhibited higher levels in plasma but decreased in saliva compared to the control group. CAT activities and UA levels in saliva (p = 0.015 and p < 0.001 respectively) were observed to be significantly higher in RAS patients. Within the RAS group elevated plasma SOD level (p < 0.006) was found in patients with major ulcers whereas, an increased plasma UA (p < 0.01) level was observed in patients with minor ulcers.
Conclusion: The non-equilibrium antioxidant levels observed in both plasma and saliva indicate the antioxidant status of the body is disturbed in patients with RAS.
Antioxidants, Catalase, Glutathione peroxidise, Recurrent aphthous stomatitis, Superoxide dismutase, Uric acid
J S Jesija, Saraswathi Gopal, Hugh P Skiel. RECURRENT APHTHOUS STOMATITIS: AN ASSESSMENT OF ANTIOXIDANT LEVELS IN PLASMA AND SALIVA. Journal of Clinical and Diagnostic Research [serial online] 2017 September [cited: 2018 Jan 18 ]; 11:ZC64-ZC67. Available from
Date of Submission: Apr 05, 2017
Date of Peer Review: Jun 07, 2017
Date of Acceptance: Jun 24, 2017
Date of Publishing: Sep 01, 2017
FINANCIAL OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2016: 132.37
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)