Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 23224

Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : EC19 - EC22

Variability of Iron Load in Patients of Sickle Cell Anaemia (HbSS): A study from Eastern India

Pranati Mohanty, Rabindra Kumar Jena, Sudha Sethy

1. Assistant Professor, Department of Pathology, S.C.B. Medical College and Hospital, Cuttack, Odisha, India. 2. Professor and Head, Department of Clinical Haematology, S.C.B. Medical College and Hospital, Cuttack, Odisha, India. 3. Assistant Professor, Department of Clinical Haematology, S.C.B. Medical College and Hospital, Cuttack, Odisha, India.

Correspondence Address :
Dr. Pranati Mohanty,
Assistant Professor, Department of Pathology, SCB Medical College and Hospital, Cuttack-753007, Odisha, India.


Introduction: Sickle Cell Anaemia (SCA) is one of the commonest haemoglobinopathies due to a point mutation (A?T) of the b-globin gene. Out of five haplotypes, the Arab-Indian haplotype present in India is one of the least severe phenotype and least studied also. It is characterized by lifelong haemolytic anaemia requiring red cell transfusion leading to iron overload. In contrast, there is very high incidence of deficiency of iron, folic acid and vitamin B12.

Aim: Our objective was to access the Iron status of SCA patients and to find its correlation with various parameters like red cell transfusion, haemolysis and serum hepcidin.

Materials and Methods: This was a cross-sectional study conducted on 208 patients for a period of five years. Complete Blood Count (CBC), iron profile, haemolytic parameters and transfusion requirement were studied and data compared with 52 healthy controls.

Results: Few patients (9.6%) revealed significant iron overload (Serum ferritin > 1000 ng/ml). In majority (80.8%) it was either normal or border line raised (300 to 1000 ng/ml) or iron deficiency was noted in a small fraction (9.6%). Frequency of transfusion is the principal factor which positively correlated with level of iron load (p<0.001) while parameters of haemolysis and serum hepcidin level play an insignificant role in this context (p= 0.0634).

Conclusion: This study supports the notion that the presentation of SCA patients in India is of “Viscosity – Vaso-Occlusive Crisis (VOC) phenotype” with high incidence of VOC, low haemolytic rate and transfusion requirement. Iron deficiency may be present in SCA patients requiring Iron supplementation. We suggest further studies to establish the role of hepcidin, ferroportin and other factors that control iron absorption in these patients.


Arab- Indian haplotype, Hepcidin, Point mutation, Red cell transfusion, Serum ferritin

How to cite this article :

Pranati Mohanty, Rabindra Kumar Jena, Sudha Sethy. VARIABILITY OF IRON LOAD IN PATIENTS OF SICKLE CELL ANAEMIA (HBSS): A STUDY FROM EASTERN INDIA. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 May 25 ]; 11:EC19-EC22. Available from

DOI and Others

DOI: 10.7860/JCDR/2017/23286.9492

Date of Submission: Aug 02, 2016
Date of Peer Review: Sep 20, 2016
Date of Acceptance: Nov 10, 2016
Date of Publishing: Mar 01, 2017


JCDR is now Monthly and more widely Indexed .
  • PubMed Central® (PMC)New
  • Academic Search Complete Database
  • Chemical Abstracts Service
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhostNew
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Open J-Gate
  • Popline (reproductive health literature)