Clinical Response of Levodopa Carbidopa Combination in Patients with Idiopathic ParkinsonismCorrespondence Address :
Dr. Abhijith Lalesh Merajoth,
Room no 13, pg Hostel for Men, Government Medical College Thiruvananthapuram, Kerala-695011, India.
Introduction: Parkinsonís disease is the most common form of a group of progressive neurodegenerative disorders. The use of levodopa as dopamine Ė replacement therapy is highly effective in ameliorating the symptoms of the disease and remains the standard drug with which other therapies are compared.
Aim: To study the change in Unified Parkinsonís Disease Rating scale (UPDRS) scores in patients receiving levodopa and carbidopa treatment (levodopa- carbidopa combination).
Materials and Methods: Study was conducted in Department of Neurology, Government Medical College, Trivandrum, India on 75 patients. All patients diagnosed with Idiopathic Parkinsonís disease (PD) satisfying inclusion criteria were enrolled into the study. Informed written consent was taken from all patients. Baseline UPDRS scores were recorded followed by reassessment at the end of six month. Data was analysed using paired t-test with help of SPSS-16 statistical software.
Results: Baseline UPDRS was collected and after 6 months of treatment, it was reassessed. Baseline total score was 49.8; the follow-up score was 39.5. A decrease in score was seen in various components of UPDRS.
Conclusion: Upon statistical analysis this difference was found to be significant, which implies that, there is improvement in patientís condition. Improvement was noted in Mentation, behaviour, mood, activities of daily living and motor functions. Hence there is positive treatment response for levodopa carbidopa therapy in patients with idiopathic PD.
Activities of daily living, Neurodegeneration, UPDRS
Abhijith Lalesh Merajoth, Pradeep Sadasivan Pillai, Thomas Iype. CLINICAL RESPONSE OF LEVODOPA CARBIDOPA COMBINATION IN PATIENTS WITH IDIOPATHIC PARKINSONISM. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Jun 24 ]; 10:FC07-FC10. Available from
Date of Submission: Sep 14, 2015
Date of Peer Review: Oct 31, 2015
Date of Acceptance: Mar 18, 2016
Date of Publishing: May 01, 2016
Financial OR OTHER COMPETING INTERESTS: None.
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