Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2016 | Month : May | Volume : 10 | Issue : 5 | Page : ED08 - ED09

Unusual Presentation of Light Chain Deposition Disease: A Case Report

Disha Arora, Mayank Uppal, Vindu Amitabh, Usha Agrawal

1. Senior Resident, Department of Pathology, Safdarjung Hospital, New Delhi, India. 2. Ex- Senior Resident, Department of Medicine, Safdarjung Hospital, New Delhi, India. 3. Head of Department, Department of Nephrology, Safdarjung Hospital, New Delhi, India. 4. Scientist E, National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.

Correspondence Address :
Dr. Disha Arora,
House Number 6, Block Number 12, First Floor, West Patel Nagar, New Delhi 110008 India.


Light Chain Deposition Disease (LCDD) is a rare disease characterized by deposition of monoclonal non-amyloid light chains in multiple organs. We report an unusual histologic manifestation of LCDD in a 55-year-old female patient, who presented with nephrotic syndrome and an increased serum creatinine. This case of LCDD had features of cast nephropathy on biopsy which is diagnostic of myeloma kidney, when the patient was clinically asymptomatic. Serum electrophoresis showed no abnormal band. There was no other evidence of a B-cell clonal disorder or amyloidosis. Following chemotherapy, improvement in renal function correlated with a reduction in circulating light-chain levels.


Cast nephropathy, Myeloma kidney, Nephrotic syndrome

How to cite this article :

Disha Arora, Mayank Uppal, Vindu Amitabh, Usha Agrawal. UNUSUAL PRESENTATION OF LIGHT CHAIN DEPOSITION DISEASE: A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Jul 22 ]; 10:ED08-ED09. Available from

DOI and Others

DOI: 10.7860/JCDR/2016/18358.7762

Date of Submission: Dec 15, 2015
Date of Peer Review: Jan 22, 2016
Date of Acceptance: Feb 29, 2016
Date of Publishing: May 01, 2016


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