Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2016 | Month : May | Volume : 10 | Issue : 5 | Page : AC01 - AC05

Early Onset of Atherosclerosis of The Carotid Bifurcation in Newborn Cadavers

Bahar Uslu, Yusuf Ozgur Cakmak, Ümit Sehirli, Elif Nedret Keskinoz, Erdal Cosgun, Serap Arbak, Aymelek Yalin

1. PhD, Department of Obstetrics and Gynaecology, Yale School of Medicine, New Haven, CT, USA. 2. Department of Anatomy, School of Medicine, Koc University, Istanbul, Turkey. 3. Department of Anatomy, School of Medicine, Marmara University, Istanbul, Turkey. 4. Department of Anatomy, School of Medicine, Acibadem University, Istanbul, Turkey. 5. PhD, Department of Biostatistics and Medical Informatics, School of Medicine, Acibadem University, Istanbul, Turkey. 6. PhD, Department of Histology & Embryology, School of Medicine, Acibadem University, Istanbul, Turkey. 7. PhD, Department of Anatomy, School of Medicine, Eastern Mediterranean University, Famagusta, Northern Cyprus.

Correspondence Address :
Dr. Bahar Uslu,
Clinical Senior Embryologist, Histologist, Yale School of Medicine, Johnson Lab. FMB 329, 224;
Department of OB/GYN & Reproductive Sciences, 333 Cedar Street New Haven CT 06520.


Introduction: The anatomy of arterial bifurcations affects blood flow and has a significant role in the development of vascular disease. Therefore, it is important to know the structural characteristics of the Common Carotid Artery (CCA) and its branches for early onset of atherosclerosis in newborns.

Aim: The present study was conducted to evaluate the characteristics of CCA in newborn cadavers. Materials and Methods: Eight carotid arteries obtained from newborn cadavers were used. The outflow to inflow area ratios was calculated to evaluate vessel diameters. Additionally, scanning electron and light microscopic investigations were conducted with tissue samples. The brachial artery of each cadaver was used as controls. Correlation between area ratios and atherosclerotic endothelial damage was determined.

Results: Light microscopic investigations demonstrated that control group sections showed no positivity for Oil red O staining, while carotid bifurcation regions depicted widespread occurrence of intimal lipid accumulations. Scanning electron microscopic examination of control group sections presented regular endothelial topography, while carotid bifurcation region topography exhibited numerous blood cells and separated endothelial cells. Fibrin accumulation on endothelial surface in low area ratios was another important finding in the examination of its endothelial surface degeneration. The above-mentioned morphological findings seemed to be quite parallel to outflow to inflow area ratio data favouring low area and degeneration.

Conclusion: The correlation between area ratios and the histological characteristic of cerebral vessels of newborn cadavers indicate that early stages of atherosclerosis began in early embryologic life.


Carotid artery, Cerebral blood flow, Cerebral haemodynamics, Endothelium

How to cite this article :

Bahar Uslu, Yusuf Ozgur Cakmak, Ümit Sehirli, Elif Nedret Keskinoz, Erdal Cosgun, Serap Arbak, et al.. EARLY ONSET OF ATHEROSCLEROSIS OF THE CAROTID BIFURCATION IN NEWBORN CADAVERS. Journal of Clinical and Diagnostic Research [serial online] 2016 May [cited: 2018 Mar 21 ]; 10:AC01-AC05. Available from

DOI and Others

DOI: 10.7860/JCDR/2016/19827.7706

Date of Submission: Feb 27, 2016
Date of Peer Review: Mar 25, 2016
Date of Acceptance: Apr 18, 2016
Date of Publishing: May 01, 2016


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