Correlation of Cytological Grading in Lymphocytic Thyroiditis with Thyroid Hormones and Antibodies - A Retrospective Study in the Era of Bethesda System of Thyroid Reporting EC01-EC04
Dr. Hemalatha Anantharamaiah,
Associate Professor, Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar-563101, Karnataka, India.
Introduction: Thyroid disorders are the most common endocrine disorders affecting about 42 million people in India. Among all the disorders, Lymphocytic Thyroiditis (LT) is the second most common thyroid lesion diagnosed on cytology next to goiter.
Aim: The present study was done to grade cytological smears of LT and correlate grades with clinical presentation, Thyroid Stimulating Hormone (TSH) and antithyroid antibodies.
Materials and Methods: The present study was a retrospective study of 185 cases from June 2014 to June 2016 conducted at Sri Devaraj Urs Medical College and Research centre, Kolar, Karnataka, India. Institutional ethical clearance was obtained before the start of study. Patientís clinical and demographic details, relevant cytology smears were retrieved and graded based on Bhatia A et al., criteria. Thyroid function tests were done in 98 cases and antithyroid antibody levels values was available in 59 cases. Chi-square test and Pearsonís correlation coefficient were used and p=0.05 was considered as significant for statistical analysis.
Results: Female preponderance in the age group of 7-60 years with diffuse thyroid enlargement was the common presentation. Maximum numbers of cases were of cytological grade 2 with euthyroid and hypothyroid status. A p-value was significant for correlation of all cytological grades with TSH values. Combination of Anti Thyroid Peroxidase (ATPO) and TSH together had positive correlation with cytological grade 3.
Conclusion: Cytological grading helps in assessing the severity of the disease as it reflects the TSH levels and ATPO levels.