Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Table of Contents - Year : 2017 | Month : August | Volume : 11 | Issue : 8 | Page : DD04 - DD06

Hepatitis B Core Antibody Negativity in a Chronic Hepatitis B Infected Patient: Report of an Unusual Serological Pattern DD04-DD06

Vijeta Bajpai, Ekta Gupta, Naveen Kundu, Shvetank Sharma, SM Shashtry

Correspondence
Dr. Ekta Gupta,
Additional Professor, Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi-110070, India.
E-mail: ektagaurisha@gmail.com

Diagnosis of Hepatitis B Virus (HBV) infection is established by the presence of various hepatitis B serological and molecular markers. Expression of these serological markers may vary in natural course of HBV infection. We report a case of an unusual HBV serological pattern in a Chronic Hepatitis B (CHB) infected patient demonstrating absence of Hepatitis B core Antibody (Anti-HBc) in spite of presence of Hepatitis B surface Antigen (HBsAg) and HBV DNA. Since, anti-HBc represents a reliable serological marker for past exposure of HBV infection, therefore we emphasize on the presence of such unusual serological pattern which could lead to doubts in the interpretation of results.