Fasting Lipid Profile and Disease Severity in Sepsis Patients OC10-OC12
Dr. B Renymol,
Associate Professor, Department of General Medicine, Government T.D. Medical College, Vandanam,
Alappuzha-688005, Kerala, India.
Introduction: Sepsis is a systemic inflammatory response syndrome that has a proven or suspected microbial aetiology. Sepsis carries significant morbidity and mortality. During sepsis many changes occur in plasma lipids and lipoproteins. These changes help in fighting inflammation and contribute to host defence. Studies have shown that there is are relationship between low cholesterol and sepsis and the levels of total cholesterol and HDL decline during sepsis.
Aim: To assess lipid profile abnormalities in patients with sepsis and to study the relation between fasting lipid profile and disease severity and mortality in patients with sepsis.
Materials and Methods: This descriptive study was done at Government TD Medical College, Alappuzha, Kerala. The duration of study was one year. A total of 70 patients who were admitted to the medical intensive care unit who satisfied the American College of Chest Physicians/ Society of Critical Care Medicine (ACCP/SCCM) criteria for the diagnosis of sepsis were included in the study. Depending on the severity of sepsis, these patients were grouped into three groups-sepsis, severe sepsis and septic shock group.
Results: Significantly lower values of HDL cholesterol and LDL cholesterol were observed in patients with severe sepsis and septic shock compared to patients with sepsis. Total cholesterol also showed lower values in patients with septic shock but this observation was statistically not significant. Triglycerides showed an inverse pattern with higher values in septic shock group.
Conclusion: It is observed that low LDL cholesterol and high Triglycerides were associated with a significantly higher mortality in patients with sepsis.