An Unusual Case of Primary Plasma Cell Leukaemia Mimicking Acute Leukaemia:
A Case Report and Review of Literature
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Correspondence
Dr. Monica Gupta,
Assistant Professor, Department of Oncopathology, Delhi State Cancer Institute, Delhi-110095, India.
E-mail: drmonica123@gmail.com
Plasma Cell Leukaemia (PCL) is rare and an aggressive disease accounting for only 2-3% of all plasma cell dyscrasias. Diagnosis is made when there are more than 2x109/L plasma cells in the peripheral blood or monoclonal plasmacytosis more than 20% of the Total Leucocyte Count (TLC). We report a case of 58-year-old male with history of high grade fever, generalized weakness and giddiness for two to three months. Peripheral blood film revealed marked leucocytosis with 88% of atypical cells resembling blasts. Flow cytometric immunophenotyping confirmed plasmacytic lineage. Bone marrow was planned but the patient deteriorated very rapidly and died within 3 days. PCL has no definitive treatment and has a dismal prognosis, requiring more extensive data to improve the disease course.