Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Table of Contents - Year : 2016 | Month : September | Volume : 10 | Issue : 9 | Page : OC24 - OC28

Association of Vitamin D Deficiency with Coronary Artery Disease OC24-OC28

Deba Prasad Dhibar, Yash Paul Sharma, Sanjay Kumar Bhadada, Naresh Sachdeva, Kamal Kant Sahu

Correspondence
Dr. Deba Prasad Dhibar,
Senior Resident, Department of Internal Medicine, PGIMER, Chandigarh, India.
E-mail: drdeba_prasad@yahoo.co.in

Introduction: Coronary Artery Disease (CAD) is a major global health problem. Recent studies demonstrated that lower vitamin D level (<30ng/ml) is associated with higher blood pressure and directly or indirectly with CAD, due to vascular endothelial damage. However the results are inconsistent.

Aim: To find the association of vitamin D deficiency with CAD

Materials and Methods: In this cross-sectional observational study, serum vitamin D level was measured in 315 patients who underwent coronary angiography.

Result: The mean (±SD) vitamin D was 13.40ng/ml (±10.40). However, the patients with normal coronary artery had much lower mean vitamin D (11.30ng/ml±9.50) as compared to the patients with CAD (14.10ng/ml±10.70). The mean (±SD) vitamin D levels were 19.00ng/ml (±16.50), 14.10ng/ml (±11.10) and 13.20ng/ml (±8.80) in patients with CAD with 50%-70%, >70%-90% and >90% stenosis respectively (p= 0.46) and 15.20ng/ml (±13.00), 15.50ng/ml (±11.30) and 11.80ng/ml (±7.00) in patients with CAD with single, double and triple vessels disease respectively (p= 0.14). The frequency of vitamin D deficiency were 66.70%, 83.20 % and 83.10% in patients with CAD with 50% -70%, >70%-90% and >90% stenosis respectively and 81.40%, 80.00% and 83.50% in patients with single, double and triple vessel disease respectively, as compared to 89.30% in patients with normal coronary artery (p= 0.41 and 0.075). So, all the study groups of CAD had low serum vitamin D level and high frequency of vitamin D deficiency, which was statistically insignificant.

Conclusion: Prevalence of vitamin D deficiency is very high in CAD, but it does not correlate with the angiographic severity of CAD.