Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Table of Contents - Year : 2016 | Month : September | Volume : 10 | Issue : 9 | Page : ED04 - ED05

Amyloidosis: The Newer Discovered ALECT2 Associated with der7q add(7) ED04-ED05

Amrita Chakrabarti, Priyanka Samal, Joydeep Chakrabartty

Correspondence
Dr. Amrita Chakrabarti,
Department of Pathology, Apollo Gleneagles Hospital, Kolkata-700054, West Bengal, India.
E-mail: amrita.chakravarti@gmail.com

Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the commonest. ALECT 2 is the newest protein described, having a predisposition to affect the kidneys, sometimes the liver and rarely other organs. We present a case of renal amyloid ALECT 2 due to leucocyte cell derived chemotaxin 2, a novel amyloidogenic protein. The patient presented with mild proteinuria, scattered plasma cells on bone marrow examination and altered kappa/lambda ratio with associated cytogenetic abnormality of der7q add(7). It is essential to correctly type this protein and differentiate it from AL during diagnosis for appropriate and effective clinical management.