Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Table of Contents - Year : 2016 | Month : July | Volume : 10 | Issue : 7 | Page : UC05 - UC08

Comparsion of Intravenous Lignocaine, Tramadol and Keterolac for Attenuation of Propofol Injection Pain UC05-UC08

Harprit Kaur Madan, Rajinder Singh, Gurdip Singh Sodhi

Dr. Harprit Kaur Madan,
101/B, Cosmos Apts, 3rd Cross Lane, Lokhandwala Complex, Andheri West, Mumbai-53, India.

Introduction: Propofol possesses many characteristics of an ideal intravenous anaesthetic agent, providing a smooth induction and a rapid recovery. However, it has been reported to evoke considerable pain on injection in 10-100% of patients. The cause of pain upon intravenous injection of propofol remains a mystery.

Aim: To study and compare the efficacy of Lignocaine, Tramadol and Ketorolac in minimizing the propofol injection pain.

Materials and Methods: Hundred adult patients (ASA grade I and grade II) scheduled for elective surgery under general anaesthesia with propofol as an inducing agent were considered for the study. Patients were randomly divided into 4 groups of 25 patients each Group L (lignocaine) Group T (tramadol) Group K (ketorolac) and Group N (normal saline). Pain scores were measured by the investigator immediately following injection of propofol. All patientsí responses were graded by a verbal pain score.

Results: All the results were tabulated and analysed using the one-way ANOVA and z-test. There was no statistically significant difference among group L (24%), T (28%) and K (28%) for pain on injection, but significant difference of all 3 groups was there when compared with group N.

Conclusion: Intravenous lignocaine, tramadol and ketorolac all 3 drugs significantly reduce propofol injection pain. However, lignocaine appears to be more acceptable cause of less pain and fewer side effects as compared to tramadol and ketorolac.