Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Table of Contents - Year : 2016 | Month : July | Volume : 10 | Issue : 7 | Page : TD01 - TD02

Cortical Clefts and Cortical Bumps: A Continuous Spectrum TD01-TD02

Asthik Biswas, Farha Furruqh, Suresh Thirunavukarasu, Ravichandran Vivekandan

Dr. Asthik Biswas,
78-Omkar Nagar, Arekere Mico Layout, Bannerghatta Road, Bengaluru-560076, Karnataka, India.

Cortical ‘clefts’ (schizencephaly) and cortical ‘bumps’ (polymicrogyria) are malformations arising due to defects in postmigrational development of neurons. They are frequently encountered together, with schizencephalic clefts being lined by polymicrogyria. We present the case of an eight-year-old boy who presented with seizures. Imaging revealed closed lip schizencephaly, polymicrogyria and a deep ‘incomplete’ cleft lined by polymicrogyria not communicating with the lateral ventricle. We speculate that hypoperfusion or ischaemic cortical injury during neuronal development may lead to a spectrum of malformations ranging from polymicrogyria to incomplete cortical clefts to schizencephaly.