Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Table of Contents - Year : 2016 | Month : July | Volume : 10 | Issue : 7 | Page : OC01 - OC05

A Prospective Study on Prevalence and Causes of Anaemia in Patients with Acute Coronary Syndrome OC01-OC05

Penta Bhavanadhar, Vangipuram Rangacharyulu Srinivasan, Sai Satish Oruganti, Krishna Prasad Adiraju

Correspondence
Dr. Penta Bhavanadhar,
Senior Resident, Department of Cardiology, Gandhi Medical College, Secunderabad,
Telangana-500003, India.
E-mail: bhavanadhar@gmail.com

Introduction: Anaemia is a contributor for adverse prognosis in Acute Coronary Syndrome (ACS), but the epidemiology and causes of anaemia in such patients is not defined.

Aim: To study the prevalence and aetiology of anaemia in hospitalized patients with ACS.

Materials and Methods: All consecutive patients admitted with ACS from January to March, 2010 were included. Their clinical information was recorded.

Results: Of 130 (87 males) consecutive admissions for ACS, 47.7% had unstable angina, 10% had Non ST-Elevation Myocardial Infarction (NSTEMI) and 42.3% had ST-Elevation Myocardial Infarction (STEMI). Overall prevalence of anaemia (haemoglobin <130 g/l in men and <120 g/l in women) was 51.5% (n=67) and was more prevalent in women (n=30, 69.8%) than men (n=37, 42.5%). Moderate to severe anaemia was more in women (34.9%) compared to men (20.8%). Anaemia was more common in unstable angina patients (58.2%) than in NSTEMI (11.9%) or STEMI (29.9%) patients (p=0.013). Aspirin (p<0.01) and/or clopidogrel intake (p<0.01) and raised serum creatinine (p<0.01) were more often in anaemic patients. Heart failure (p<0.01) and triple vessel disease (p<0.05) were associated with anaemia. Multivariate predictors of duration of hospital stay were haemoglobin (p<0.05) at admission and revascularisation procedure (p=0.01) during hospital stay. The most common cause of anaemia was iron deficiency (29.9%).

Conclusion: Anaemia was common in our patients admitted with ACS. Female gender, antiplatelet drug intake and raised creatinine were associated with anaemia, which in turn was associated with adverse in-hospital outcomes. The impact of correcting anaemia on outcomes in ACS needs long term prospective study.