Red Lentil Extract: Neuroprotective Effects on Perphenazine Induced Catatonia in Rats FF05-FF08
Dr. Gholamreza Houshmand,
Department of Pharmacology and Toxicology, School of Pharmacy,
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Introduction: Parkinsonism is a neurodegenerative disease that is defined by certain symptoms such as muscle rigidity, impaired movement, catatonia, tremor and disorientation of body.
Aim: The aim was to investigate the effect of red lentil extract on perphenazine-induced Catatonia in model of rat.
Materials and Methods: This experimental study was done on 48 male albino rats (weight 180–200g) of the Sprague-Dawley strain. Animals were randomly divided into six groups and were pre-treated with a single dose of red lentil extract (200, 400, 800 and 1000 mg/kg), most effective dose of bromocriptine (30mg/kg) and normal saline (5ml/kg) via intraperitoneal (IP) route. perphenazine (5 mg/kg) was after 30 minutes, administered (IP) to induce catatonia. The scoring method of Morpurgo was used to determine the muscular rigidity of animals.
Results: The results showed that the 200mg/kg red lentil extract treated group had no significant reduction in catatonic responses after perphenazine administration in comparison with control group while the groups that received 800 and 1000mg/kg of red lentil extract showed significant difference (p<0.05) at all the time points.
Conclusion: The results revealed that hydroalcoholic extract of red lentil has protective effect on Catatonia induced by perphenazine in rats. So this extract may be probably beneficial for catatonia in Parkinsonism.