Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Table of Contents - Year : 2016 | Month : April | Volume : 10 | Issue : 4 | Page : VD01 - VD02

Behavioural Variant Frontotemporal Dementia with Bilateral Insular Hypometabolism: A Case Report VD01-VD02

Ananya Mahapatra, Mamta Sood, Roshan Bhad, Manjari Tripapathi

Dr. Ananya Mahapatra,
Department of Psychiatry, 4th Floor, Teaching Block, All India Institute of Medical Sciences,
Ansari Nagar, East, New Delhi-110029 ,India.

Fronto-Temporal Dementia (FTD) is a cluster of syndromes, characterized by progressive deterioration of cognition, language and/or behavioural changes associated with degeneration of the frontal and temporal lobes. A 53-year-old man was admitted with a history of gradually progressive behavioural disturbances, disinhibition, unprovoked anger outbursts, apathy, disorganised behaviour and impaired self-care. A clinical diagnosis of Fronto temporal Dementia (behavioural variant) was made. Extensive investigations found no abnormality except in FDG-PET scan of the brain which revealed hypo metabolism in bilateral anterior insular region. Insula is an important brain area implicated in emotional awareness and behaviour control. Hypo metabolism in insular region in the absence of any structural neuroimaging findings, in a case of behavioural variant of Fronto-temporal dementia suggest that, it might be one of the earliest neurobiological changes occurring in this disorder.