Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Table of Contents - Year : 2012 | Month : August | Volume : 6 | Issue : 6 | Page : 1011 - 1013

Vitamin D in Ulcerative Colitis: A Cause or an Effect? 1011-1013

Taghi Amiriani, Somaye Barzanoni, Sima Sedighy, Sima Besharat, Fatemeh Nejadi Kelarijani, Hamidreza Joshaghani, Gholamreza Roshandel, Hamide Akbari

Dr. Sima Besharat
3rd Floor, Shahid Nabavi polyclinic,
4th Azar Alley, 5-Azar St, Gorgan City,
Golestan province, Iran.
Phone: 0098-171-2240835

Background and Aims: Vitamin D deficiency is common among patients with inflammatory bowel disease, even when the disease is in remission. This study was designed to evaluate the serum levels of 25-hydroxy vitamin D [25(OH)-D3] in patients who suffered from ulcerative colitis and the control group in Golestan province in the northeast of Iran.

Methods: In this case-control study, 60 patients with a definite histopathological diagnosis of ulcerative colitis were included. The control group was selected from healthy blood donors. The serum levels of 25(OH)-D3 were measured by the ELISA method (ids- UK). Data were entered into the SPSS-16 software and were analyzed by t-test and Chi-square test.

Results: The mean serum level of vitamin D in the patients was significantly lower as compared to that in the control group (P-value <0.01). The differences in the levels of 25-OH-D3 were statistically significant between the two sexes, in both groups. A normal vitamin D level was seen in all cases with proctitis, in 20% of cases in the rectosigmoiditis group and in no cases in the pan-colitis group. The difference was statistically significant (p-value <0.01).

Conclusions: It can be concluded that the serum levels of vitamin D in the patients with ulcerative colitis are low and that inflammatory bowel disease can be a target for the specific vitamin D therapy.