A Comparative Study of Pseudocholinesterase
and Liver Function Test in
Cirrhosis of Liver, Infective Hepatitis and
Obstructive Jaundice: A Case Control Study
S. Venkata Rao, V.S. Ravi Kiran, S. Indira
Dr. S. Venkata Rao, Bsc., M.D.,
Professor & HOD, Department of Biochemistry,
Katuri Medical College, Katuri Nagar,
Chinakondrupadu, Guntur- 522 019,
Andhra Pradesh, India.
ectives:docholinesterase is a non-specific cholinesterase found in the blood plasma and may be reduced in patients with advanced liver disease. A comparative study of Pseudocholinesterase along with other liver function test parameters were undertaken in different liver disorders. The aim of the present was to investigate Pseudocholinesterase as a probable diagnostic marker in different liver disorders.
MethodsA Totle25 age and sex matched healthy controls and 25 patients each from cirrhosis of liver, infective hepatitis and obstructive jaundice were included in the study. Plasma Pseudocholinesterase and other liver function test parameters were estimated in all the subjects. ANOVA statistics was used.
Results: Pseudocholinesterase level was significantly decreased in the order of control (mean ± SD = 7.34400 ± 2.29875) > obstructive jaundice (mean ± SD = 3.23600 ± 0.61161) > infective hepatitis (mean ± SD = 2.27600 ± 0.63527) > cirrhosis of liver (mean ± SD = 1.85200 ± 0.27226) respectively. The difference in the means was statistically significant as p = 0.0000001.
Conclusions: Our study showed a significant decrease in Pseudocholinesterase level in cirrhosis of liver than infective hepatitis and obstructive jaundice. The results indicated that with more severe liver cell destruction, reduction and disease, there was corresponding significant decrease in the level of Pseudocholinesterase and could be used as diagnostic marker of liver disease.
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