Quantitative Assessment of Interleukin-6 and Ferritin Levels and its Clinical Correlation among COVID-19 PatientsCorrespondence Address :
Dr. MP Sujatha,
Associate Professor, Department of Anaesthesiology, Sri Devaraj Urs Academy of
Higher Education and Research, Tamaka, Kolar-563103, Karnataka, India.
Introduction: COVID-19 pandemic has emerged as a global challenge threatening human life worldwide. Early recognition of severe forms of COVID-19 infection is critically essential for timely triaging of COVID-19 patients. Biochemical Parameters correlating clinically with the severity of COVID-19 infection amidst testing of Peripheral Oxygen Saturation (SpO2 ) levels can serve in timely management of severe COVID-19 infections.
Aim: To estimate the concentrations of proinflammatory cytokine serum Interleukin-6 (IL-6) and serum ferritin levels and to clinically correlate these markers with COVID-19 disease severity.
Materials and Methods: A cross-sectional single center study conducted in a tertiary care hospital and research center from July 2020 to September 2020, 113 COVID-19 positive patients confirmed by Real Time-Polymerase Chain Reaction (RT-PCR) were included, Serum IL-6 and Serum Ferritin levels were measured in the patientâ€™s blood sample using standard Enzyme linked Immunosorbent Assay (ELISA) and Vitros ECi Immunodiagnostics respectively. Data obtained was statistically analyzed using Statistical Package for the Social Science (SPSS) Software version 22.0.
Results: Of the 113 COVID-19 infected patients, 53 were included in Group A, 27 patients in Group B and 33 patients in Group C. Mean±SD of Serum IL-6 levels were 10.92±2.65, 40.05±11.66 and 120.92±40.96 pg/mL (p<0.001) and Serum Ferritin levels 368.21±374.85, 309.15±291.58, and 433.45±376.13 ng/mL, respectively.
Conclusion: IL-6 correlated significantly with disease severity of COVID-19 infection and can be judiciously used for stratification and management of COVID-19 infected patients. Serum Ferritin concentration were found to be high in severe cases of COVID-19 infections and did not show any significant variation compared with mild to moderate COVID-19 infection.
Acute phase protein, Proinflammatory cytokine, Severe acute respiratory syndrome coronavirus-2
Date of Submission: Jan 30, 2021
Date of Peer Review: Mar 04, 2021
Date of Acceptance: Apr 03, 2021
Date of Publishing: May 01, 2021
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
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ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)