Rhino-Orbital-Cerebral Mucormycosis Causing Orbital Apex Syndrome and BlindnessCorrespondence Address :
Dr. Saif Abdulghani Alghamdi,
Abdulaziz Almubarak Street, Unit No. 21, Jeddah-23466-3461, Saudi Arabia.
Mucormycosis is a potentially fatal fungal infection caused by a group of molds called mucormycetes. Rhino-Orbital-Cerebral Mucormycosis (ROCM) represents nearly half of all cases. This is the case of a 46-year-old female recently diagnosed with leukaemia and was started on chemotherapy. After initiating chemotherapy, she complained of headache, blurring of vision in the right eye and nasal discharge. Examinations revealed orbital apex syndrome. MRI disclosed an inflammation affecting the right orbit, ethmoid sinus and the frontal lobe. Ethmoidectomy was performed and biopsies confirmed mucormycosis. After that, symptoms persisted and complete loss of vision in her right eye occurred. Right orbital exenteration was required. The response was noticed over the subsequent weeks until she became asymptomatic. Five weeks after initially being diagnosed with leukaemia, she entered remission and was discharged on oral itraconazole and oral retinoic acid. Later, she remained in complete remission. In conclusion, early suspicion and diagnosis especially in immunocompromised patients with early aggressive treatment can be life saving.
Eye infection, Orbit, Orbit evisceration
Musab Abdulaziz Alsubaie, Saeed Abdullah Alghamdi, Saif Abdulghani Alghamdi, Ahmed Mohammed Abdelaal, Mohamed Bakhit Satti. RHINO-ORBITAL-CEREBRAL MUCORMYCOSIS CAUSING ORBITAL APEX SYNDROME AND BLINDNESS. Journal of Clinical and Diagnostic Research [serial online] 2018 April [cited: 2019 Nov 13 ]; 12:ND01-ND03. Available from
Date of Submission: Jul 26, 2017
Date of Peer Review: Sep 01, 2017
Date of Acceptance: Dec 26, 2017
Date of Publishing: Apr 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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