A Case of Sepsis-induced MODS in Disseminated Filariasis: Cause or Co-incidence
Correspondence Address :
Dr. Rashmi Mishra,
Assistant Professor, Department of General Medicine, Maulana Azad Medical College, New Delhi-110002, India.
E-mail: rashmi.virgo02@gmail.com
Filariasis, an affliction caused by thread-like filarial worms, poses a formidable health challenge in India, with diverse regional endemicities. It manifests in two distinct forms: lymphatic and extralymphatic. The former induces agonising limb swelling, while the latter, often overlooked due to its atypical presentation, can affect various organs. The present a noteworthy case involving a 25-year-old woman who succumbed to septic shock, displaying Multiple Organ Dysfunction Syndrome (MODS). The patient exhibited bicytopaenia, leukocytosis, and progressively deteriorating liver and kidney functions, culminating in Acute Respiratory Distress Syndrome (ARDS). Postmortem examinations, conducted with proper consent, revealed sheathed microfilaria in liver and bone marrow tissues. This rare multisystem involvement in filariasis, leading to a fulminant course, raises questions about potential immunosuppression triggered by disseminated filarial dissemination. The hypothesis centres on the notion that the systemic spread of filaria might underlie the severe and rapid deterioration observed in this unique case, shedding light on the intricate dynamics of this parasitic disease and its implications for immune function.
Extra lymphatic, Multiple organ dysfunction syndrome, Immunosuppression
DOI: 10.7860/JCDR/2024/67876.19124
Date of Submission: Oct 05, 2023
Date of Peer Review: Dec 08, 2023
Date of Acceptance: Jan 17, 2024
Date of Publishing: Mar 01, 2024
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. No
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Oct 05, 2023
• Manual Googling: Dec 14, 2023
• iThenticate Software: Jan 12, 2024 (4%)
ETYMOLOGY: Author Origin
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