An Early and Rare Second Malignancy in A Treated Glioblastoma Multiforme: Is It Radiation or Temozolomide?Correspondence Address :
Dr. Sasidharan Balukrishna,
Associate Professor, Department of Radiotherapy, Unit I, Christian Medical College, Vellore-632004, India.
E-mail : firstname.lastname@example.org
Glioblastoma Multiforme (GBM) is a high-grade brain tumour with the most dismal prognosis. There are very few reports on second malignancies occurring in GBM patients, as the survival has been short. Second malignancies have been reported after treatment of malignancies with radiation therapy and chemotherapy especially after 5 to 10 y of treatment. Here in, we present a very unique case where a patient succumbed to sinonasal carcinoma occurring one and half years after treatment of GBM. A 17-year-old boy was diagnosed to have GBM and underwent surgery followed by chemoradiation and adjuvant chemotherapy with Temozolamide. He presented with undifferentiated sinonasal carcinoma, in the sinonasal region outside the radiation field within two years of treatment. Here we discuss the histology and possible chances of it being a second malignancy.
Long term chemotherapy, Radiation induced cancer, Sinonasal undifferentiated carcinoma
Shina Goyal, Rabi Raja Singh, Sasidharan Balukrishna,
Mandeep Bindra, Selvamani Backianathan. AN EARLY AND RARE SECOND MALIGNANCY IN A TREATED GLIOBLASTOMA MULTIFORME: IS IT RADIATION OR TEMOZOLOMIDE?. Journal of Clinical and Diagnostic Research [serial online] 2015 April [cited: 2019 Aug 17 ]; 9:TD05-TD07. Available from
Date of Submission: Feb 18, 2015
Date of Peer Review: Mar 15, 2015
Date of Acceptance: Mar 23, 2015
Date of Publishing: Apr 01, 2015
Financial OR OTHER COMPETING INTERESTS: None.
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