Comparative Effect of Cinnamon and Ibuprofen for Treatment of Primary Dysmenorrhea: A Randomized Double-Blind Clinical TrialCorrespondence Address :
Dr. Ali Khani,
Nursing & Midwifery Faculty, Ilam University of Medical Science, Ilam, IR-Iran.
E-mail : email@example.com
Background and Aims: Primary dysmenorrheal has a negative impact on women's quality of life. The purpose of this study was to compare the effect of Cinnamon and Ibuprofen for treatment of primary dysmenorrheal in a sample of Iranian female college students from Ilam University of Medical Sciences (western Iran).
Materials and Methods: In a randomized, double-blind trial, out of 114, control group received placebo (empty capsules contain starch, TDS, n= 38) a test group received Ibuprofen (capsule containing 400mg Ibuprofen, TDS, n=38), or another test group received Cinnamon (capsule containing 420 mg Cinnamon, TDS, n= 38) in 24 h. To determine severity of pain, we used the VAS scale. Pain intensity and duration of pain were monitored in the group during first 72 h of cycle.
Results: The mean pain severity score and mean duration of pain in Ibuprofen and Cinnamon were less than placebo group respectively (p< 0.001). Of 4 hours after the intervention there were no statistically significant differences between the Cinnamon and placebo group (p> 0.05). Of eight hours after the intervention, the mean pain severity in the cinnamon group was significantly lower than placebo group (p< 0.001). At various time intervals the mean pain severity in the Ibuprofen group were significantly less than Cinnamon and placebo groups (p< 0.001).
Conclusion: Cinnamon compared with placebo significantly reduced the severity and duration of pain during menstruation, but this effect was lower compared with Ibuprofen. Cinnamon can be regarded as a safe and effective treatment for primary dysmenorrhea. More researches are recommended to study the efficacy of Cinnamon on reducing menstrual bleeding.
Medicinal herbal, Menstruation, Pain
Molouk Jaafarpour, Masoud Hatefi, Ali Khani, Javaher Khajavikhan. COMPARATIVE EFFECT OF CINNAMON AND IBUPROFEN FOR TREATMENT OF PRIMARY DYSMENORRHEA: A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL. Journal of Clinical and Diagnostic Research [serial online] 2015 April [cited: 2019 Aug 23 ]; 9:QC04-QC07. Available from
Date of Submission: Nov 12, 2014
Date of Peer Review: Feb 23, 2015
Date of Acceptance: Mar 02, 2015
Date of Publishing: Apr 01, 2015
Financial OR OTHER COMPETING INTERESTS: None.
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