Effect of Platelet Rich Fibrin (PRF) on Peri-implant Soft Tissue and Crestal Bone in One-Stage Implant Placement: A Randomized Controlled TrialCorrespondence Address :
Dr. Manu Rathee,
Senior Professor and Head, Department of Prosthodontics, Post Graduate Institute of Dental Sciences,
Pt. B.D Sharma University of Health Sciences, Rohtak, Haryana-124001, India.
Introduction: The viability of Platelet Rich Fibrin (PRF) on enhancement of osseous and associated tissue healing has been substantiated well in literature. However, paucity in the applicability of PRF to enhance peri-implant healing in oral region is not well-corroborated.
Purpose: This prospective study evaluated the effect of Platelet PRF on peri-implant tissue response following one-stage implant placement with non-functional immediate provisionalization in maxillary anterior region.
Materials and Methods: A Prospective, Randomized Controlled Trial (RCT) was conducted across 20 (15 male, 5 Female) systemically healthy subjects with maintainable oral hygiene. Subjects were broadly divided into two groups i.e. Study group (PRF group) and Control group (Non-PRF group). Twenty standard SLA- AB/AE (alumina oxide blasted/acid etched surface treated) tapered threaded dental implants were randomly placed with and without PRF and immediately provisionalized. The subjects were evaluated clinically and radiographically at baseline (at time of implant placement), one month and three month post-operatively for peri-implant soft tissue and crestal bone responses.
Results: At 3 months, all implants remained osseointegrated. The mean marginal bone changes were observed from baseline to 3 months in both groups with lesser changes observed in PRF Group. No significant differences in probing depth and bleeding on probing were noted during follow-up.
Conclusion: Within the limitations of this study, PRF could be considered as a healing biomaterial with potential beneficial effect on peri-implant tissue and can be used as a therapeutic adjuvant in clinical scenario of one stage, single tooth implant placement procedure in maxillary anterior region.
Dental Implants, Fibrin membrane, Immediate loading
Priyanka Boora, Manu Rathee, Mohaneesh Bhoria. EFFECT OF PLATELET RICH FIBRIN (PRF) ON PERI-IMPLANT SOFT TISSUE AND CRESTAL BONE IN ONE-STAGE IMPLANT PLACEMENT:
A RANDOMIZED CONTROLLED TRIAL. Journal of Clinical and Diagnostic Research [serial online] 2015 April [cited: 2019 Sep 18 ]; 9:ZC18-ZC21. Available from
Date of Submission: Dec 22, 2014
Date of Peer Review: Jan 19, 2015
Date of Acceptance: Feb 13, 2015
Date of Publishing: Apr 01, 2015
Financial OR OTHER COMPETING INTERESTS: None.
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