Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Bengaluru.
On Aug 2018




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Dr. Rajendra Kumar Ghritlaharey

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Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
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Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011

Important Notice

Case report
Year : 2012 | Month : May | Volume : 6 | Issue : 4 | Page : 720 - 722

Primary Renal Squamous Cell Carcinoma: A Case Report

Md Khader Faheem N.

1. Assistant Professor, Dept. of Pathology, S.V. Medical College, Tirupati, AP, India.

Correspondence Address :
Dr. Md. Khader Faheem N.
6-7-583, Sripuram Colony, Tirupati, India - 517507
Phone: +919989610786
E-mail: faheemkhader@gmail.com

Abstract

Primary renal squamous cell carcinoma is a rare malignancy of the upper urinary tract. Very few of such cases have been reported in the world literature. The diverse aetiological factors, the non-specific clinical presentation and the radiological findings of this tumour lead to a difficulty in its diagnosis. The diagnosis is established only after the histopathological examination of the resected specimen. The case which has been reported here was a case of primary renal squamous cell carcinoma in the left kidney with multiple calculi and hydronephrosis.

Keywords

Calculi, Kidney, Squamous cell carcinoma

How to cite this article :

Md Khader Faheem N.. PRIMARY RENAL SQUAMOUS CELL CARCINOMA: A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2012 May [cited: 2019 Nov 15 ]; 6:720-722. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2012&month=May&volume=6&issue=4&page=720-722&id=2170

Introduction
Primary malignant tumours of the renal pelvis are relatively rare; these constitute about 8%-14% of all the renal malignancies (1). Urothelial carcinomas are observed in more than 90% of the cases and squamous cell carcinomas are seen only in 0.7%-7% (2). Renal squamous cell carcinoma is a rare malignancy of the upper urinary tract and it occurs six times more frequently in the renal pelvis than in the ureter. These are moderately to poorly differentiated tumours which are more likely to be invasive and in advanced stages at the time of their diagnosis (3),(4). Most of the patients have a history of chronic urolithiasis, renal infection or analgesic abuse (5). Very few cases of primary squamous cell carcinoma of the kidney have been reported in the literature. Solid masses, hydronephrosis and calcifications are common, but these are nonspecific radiological findings. The diagnosis is established only after the histopathological examination of the resected specimen. An early metastatic spread is common and the prognosis is poor, with only very few patients surviving longer than 5 years (4),(5). The case which has been reported here had squamous cell carcinoma of the renal pelvis with hydronephrosis and renal calculi. The tumour was diagnosed only after the resection of the specimen and histopathological evaluation.

Case Report

A 54-year old female, a housewife of a low socioeconomic status, presented with left flank pain which radiated to the scapular region and intermittent haematuria since one month. There was a history of intermittent pain in the abdomen with pain in the left iliac fossa since one year. The clinical examination revealed left sided abdominal fullness and tenderness. The routine lab investigations were performed; haemoglobin was 10.2 gms% and the peripheral smear showed neutrophilic leukocytosis. The platelet count was 5.1 lakh cells/cu.mm. The erythrocyte sedimentation rate (ESR) was 26 mm after the 1st hour. A urinalysis revealed haematuria and pyuria. The urine culture showed Proteus. Radiological investigations were done. A plain X ray of the abdomen (AP view) showed hazy opaque shadows in the left kidney. Intravenous pyelography (IVP) revealed an enlarged left kidney, a normal contour with a faint nephrogenic phase and multiple stones in the pelvis and the calyces (Table/Fig 1). Ultrasound of the abdomen showed an enlarged left kidney with multiple hyper echoic lesions, with posterior shadowing in the left kidney, which was suggestive of multiple large renal calculi with hydronephrosis. The case was diagnosed as a left nonfunctional kidney and total nephrectomy (left kidney) was performed. It was observed during surgery that the left kidney was attached to the peri renal tissue, showing hyperaemia, inflammation and intense adhesions. The specimen was subjected to a histopathological examination (Table/Fig 2).

The gross examination showed that the left kidney measured 11.2 x 5.5 x 4 cms. The surface was smooth anteriorly and the posterior surface showed a reddish brown scar due to the dissection of the adhesions. The cut section showed four large staghorn type of calculi and multiple small calculi of round to irregular shapes, the largest one measuring 5 x 4 cms and studded in the renal parenchyma. Surrounding these calculi, the tissue showed hyperaemic and necrotic areas with grey white nodular areas of 3 x 2 cms, extending into the cortex and the renal capsule (Table/Fig 3).

Microscopically, the gray white areas showed a well differentiated squamous cell carcinoma with keratin pearls and nests of large, atypical epithelial cells. The surrounding areas showed a chronic inflammatory reaction with focal necrosis and abortive tubules (Table/Fig 4) ,(Table/Fig 5).

Thus, after deriving the final diagnosis, the patient was subjected to thorough clinical and radiological examinations in order to search for metastatic lesions. There was no evidence of any lymph nodal enlargement or distant metastases. An active follow up of the case was done with regular evaluation and there was no evidence of any metastases or recurrence of the disease till six months. The patient was advised to attend the follow up clinic once a month.

Discussion

Primary malignant tumours of the renal pelvis are relatively uncommon, comprising of only 8-14% of all the renal malignancies (1). The most common renal malignancy in adults is clear cell carcinoma, followed by papillary carcinoma and chromophobe cell carcinoma (4),(6). Squamous cell carcinoma of the renal collective system is a rare malignancy with a poor prognosis, accounting for about 10% of the renal pelvic tumours and 0.5% of the renal tumours (6),(7).

Squamous cell carcinoma of the urothelial tract is thought to arise through a process of metaplasia of the urothelium. A majority of the patients have squamous metaplasia of the adjacent urothelium. The aetiological factors, namely long standing staghorn calculi and infections are the leading ones. Other factors include exogenous and endogenous chemicals, vitamin A deficiency, hormonal imbalance, schistosomiasis and smoking (8). However, some cases have been reported where no apparent aetiological factor could be detected (1),(9). Squamous metaplasia in the adjacent mucosa is reported in 17-33% of the patients (10). 94% of the renal squamous cell carcinomas usually present in an advanced stage at the time of the initial diagnosis. 21% of the patients are reported to be not eligible for surgery due to associated co-morbidities or advanced diseases (5),(11). An early metastatic spread is common and the prognosis is poor, with only 7.7% of the cases surviving more than 5 years. A median 5-11 month survival has been reported in a previous case series (6),(12).

Hypercalcaemia, leucocytosis and thrombocytosis have been reported to be a part of the paraneoplastic syndromes in renal squamous cell carcinoma (13).

The diagnosis is often missed due to nonspecific features i.e., solid mass, hydronephrosis and calcifications which are common radiologic findings. Some specific findings such as an enhancing extraluminal and exophytic mass on the CT scan were described in previous case reports (14).

Nephrectomy with or without ureterectomy is performed in such cases. Nephrectomy is necessary even in the face of metastatic disease; to establish a histological diagnosis, for the control of the symptoms such as – pain, fever and haematuria, or to eliminate the source of the infection before a systemic chemotherapy can be instituted. Cisplatinum based chemotherapy and palliative radiotherapy have been advocated for the control of the local symptoms in metastatic disease, but they have failed to show any survival benefit (5),(6).

In a study which was done by Lee et al., (14), primary renal squamous cell carcinoma was classified into two categories based on the location of the tumour – the central and the peripheral types. The central type had more rates of lymph nodal metastasis and the peripheral type showed parenchymal thickening with peri renal infiltration. The central type had poorer survival rates. The present case was a peripheral type of primary renal squamous cell carcinoma as per Lee et al., Nativ et al., (15), performed a study in which renal squamous cell carcinoma was divided into three groups. The report of the study stated that the one and two year survival rates of locally invasive renal squamous cell carcinoma were 33% and 22% respectively.

Biopsies from the renal pelvis or the calyceal wall should be considered in cases of long standing large renal calculi, especially in cases of staghorn calculus. Such patients are susceptible for harbouring occult or overt malignancy along with the renal stone disease (16).

Conclusion

The diagnosis of squamous cell carcinoma of the kidney is difficult on clinical grounds. It is a diagnostic challenge. Radiological investigations can only give information regarding hydronephrosis, calculus or the presence of any growth (tumour) but, they may not give an accurate diagnosis. A histopathological examination helps in deriving an accurate diagnosis, as was seen in the present case. The present article emphasizes the importance of a combined clinical, radiological, surgical and histopathological approach. The possibility of a malignancy should always be kept in mind in all the complicated cases and a histopathological examination should be performed in all the cases without fail.

Acknowledgement

I would like to thank all my colleagues and students who contributed to this study. I am grateful to my beloved Professor Dr.M.Janaki, Professor and Head, Dept. of Pathology, Kurnool Medical College, Kurnool, for her kind and needful support in my career. I thank all the staff members of the Department of Radiology, the Department of General Surgery, the Department of General Medicine and the Department of Urology, Kurnool Medical College, Kurnool who were always helpful to me during the preparation of this case report.

References

1.
Tyagi N, Sharma S, Tyagi SP, Maheshwari V, Nath P, Ashraf SM, et al. A histopmorphologic and an ultrastructural study of the malignant tumors of the renal pelvis. J Postgrad Med 1993; 39:197-201.
2.
Mizusawa H, Komiyama I, Ueno Y, Maejima T, Kato H. Squamous cell carcinoma in the renal pelvis of a horse shoe kidney. Int J Urol 2004; 11:782-84.
3.
Flanigen RC., Urothelial Tumours of the Upper Urinary tract. In: Alan J. Wein, editor. Campbell-Walsh Urology, 9th ed. China: Saunders Elsevier; 2007; 1638-52.
4.
Li MK, Cheung WL. Squamous cell carcinoma of the renal pelvis. J Urol 1987; 138:269-71.
5.
Holmang S, Lele SM, Johansson SL. Squamous cell carcinoma of the renal pelvis and the ureter: incidence, symptoms, treatment and outcome. J Urol. 2007; 178:51-56.
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Blacher EJ, Johnson DE, Abdul-Karim FW, Ayala AG. Squamous cell carcinoma of renal pelvis. Urology 1985; 25:124-6.
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Busby JE, Brown GA, Tamboli P, Kamat AM, Dinney CP, Grossman HB et al., Upper urinary tract tumors with non-transitional histology: a single-center experience. Urology. 2006; 67:518-23.
8.
Mathur SK, Rana P, Singh S, Goyal V, Sangwan M. An incidentally detected squamous cell carcinoma in a non-functioning kidney, presenting as a multi-cystic mass. Jour Surg Case reports 2011; 9:1-4.
9.
Talwar N, Dargan P, Arora MP, Sharma S, Sen AK. Primary squamous cell carcinoma of the renal pelvis masquerading as pyonephrosis: A case report. Indian J PatholMicrobiol 2006;49:418-20.
10.
Melamed MR, Reuter VE. Pathology and staging of urothelial tumours of the kidney and the ureter. Urol Clin North Am 1993;20:333-47.
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Bostrom PJ, Soloway MS. Upper urinary tract cancer–challenges for the urologist. J Urol. 2007;178:12-13.
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Kimura T, Kiyota H, Asano K, Madarame J, Yoshino Y, Miki K, et al., Squamous cell carcinoma of the renal pelvis with inferior vena caval extension. Int J Urol.2000;7:316-9.
13.
Er O, Coskun HS, Altinbas M, Akgün H, Cetin M, Eser B, et al., Rapidly relapsing squamous cell carcinoma of the renal pelvis associated with paraneoplastic syndromes of leukocytosis, thrombocytosis and hypercalcemia. Urol Int. 2001;67:175-7.
14.
Lee TY, Ko SF, Wan YL, Cheng YF, Yang BY, Huang DL, et al., Renal squamous cell carcinoma: CT findings and clinical significance. Abdom Imaging 1998; 23:203-8.
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15. Nativ O, Reiman HM, Lieber MM, Zincke H. Treatment of primary squamous cell carcinoma of the upper urinary tract. Cancer 1991; 68:2575-8.
16.
Singh V, Sinha RJ, Sankhwar SN, Mehrotra B, Ahmed N, et al. Squamous cell carcinoma of the kidney – rarity redefined: case series with review of literature. J Cancer SciTher 2010; 2:82-5.

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ID: JCDR/2012/4321:0046

Date of Submission: Mar 21, 2012
Date of peer review: Apr 18, 2012
Date of acceptance: May 16, 2012
Date of Publishing: May 31, 2012

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