Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




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Dr. Mamta Gupta
Consultant
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Dr. Rajendra Kumar Ghritlaharey

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Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011

Important Notice

Original article / research
Year : 2012 | Month : May | Volume : 6 | Issue : 4 | Page : 696 - 699

A Non-operative Treatment of Perforated Peptic Ulcer: A Prospective Study with 50 Cases

Hanumanthappa M.B., Gopinathan S., Guruprasad Rai D., Neil Ds ouza

1. Associate Professor 2. Assistant Professor 3. Resident 4. Resident NAME OF DEPARTMENT (S)/INSTITUTION(S) TO WHICH THE WORK IS ATTRI BUTED: Department of Surgery, AJ Institute of Medical Sciences, Mangalore, India.

Correspondence Address :
Hanumanthappa M.B.
AJ Institute of Medical Sciences ,
Department of Surgery, Kuntikana
Mangalore, India - 575004
Phone: 9845170266
E-mail: mb.hanumanthappa@gmail.com

Abstract

Background and Objectives: Perforation remains a major life threatening complication of peptic ulcer disease. Surgery has been the conventional treatment for it. The results of the surgery are excellent, but they are associated with morbidity and mortality. Wangensteen, in 1935 and Taylor, in 1946 have shown that a non-operative treatment is safe and effective in selected patients because the peptic perforations frequently get sealed spontaneously by the omentum and the adjacent organs. We undertook a prospective study to evaluate the results and to assess the feasibility of a non-operative treatment for perforated peptic ulcers.

Materials and Methods: This prospective case series study was carried out at the AJ Medical College, Mangalore, Karnataka, India, from Dec 2009 to Dec 2011.We studied 50 cases with a clinical diagnosis of perforated peptic ulcer. The inclusion criteria were a clinical diagnosis of perforation in less than 12 hours with a stable haemodynamic condition, age -20-70 years and a X-ray and/or a CT evidence of a pneumoperitoneum. The conservative management consisted of nil by mouth, nasogastric suction, IV fluids, intravenous antibiotics and IV Omeprezole.

Results: Out of the 50 cases, 41 (82%) cases responded well, while the remaining 9 cases failed to improve and they required emergency laparotomy. 11 of the 41 cases in the successful group developed complications, which were managed successfully and they didn’t prolong their hospital stay. The conservative management didn’t increase the morbidity significantly.

Conclusion: We conclude that the conservative treatment for perforated peptic ulcer can be safely adopted in selected patients, provided strict inclusion criteria and guidelines are followed.

Keywords

Perforation, Peptic ulcer disease, Non-operative treatment

How to cite this article :

Hanumanthappa M.B., Gopinathan S., Guruprasad Rai D., Neil Ds ouza. A NON-OPERATIVE TREATMENT OF PERFORATED PEPTIC ULCER: A PROSPECTIVE STUDY WITH 50 CASES. Journal of Clinical and Diagnostic Research [serial online] 2012 May [cited: 2019 Nov 15 ]; 6:696-699. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2012&month=May&volume=6&issue=4&page=696-699&id=2133

INTRODUCTION
Peptic ulcer disease is one of the most prevalent diseases of the gastrointestinal tract. The common complications of peptic ulcer disease are bleeding, perforation and obstruction. Perforation remains a major life threatening complication. Duodenal, antral and gastric body ulcers account for 60%, 20% and 20% ulcers among the peptic ulcer perforations respectively. The current treatment of perforated peptic ulcer is surgical repair (1). Although the results of surgery are excellent, these are associated with morbidity and mortality. The non-operative treatment, which was first proposed in 1935 by Wangensteen (2), has been shown to be safe and effective in selected patients (3). It has been known that perforated ulcers frequently get sealed spontaneously by the adherence of the omentum and the adjacent organs (1). The first conservative treatment series for perforated peptic ulcer was described by Taylor in 1946 (4). However, he proposed it for cases that were in a good general condition (5), (6),(7). We undertook a prospective study to evaluate the results and to assess the feasibility of the conservative treatment for perforated peptic ulcer.

Material and Methods

This prospective case series study was carried out in the Department of Surgery, AJ Institute of Medical Sciences, Mangalore, India, from Dec 2009 to Dec 2011.The total number of cases which was studied was 50. The clinical details are shown in (Table/Fig 1). All the 50 patients underwent a detailed clinical examination, routine haematological investigations, serum electrolytes, X-ray of the erect abdomen and USG of the abdomen. In doubtful cases, a CT scan with an oral contrast was done. The inclusion criteria consisted of a clinical diagnosis of per- foration in less than 12 hours (2) with a stable haemodynamic condition (3), age -20-70 years and a X-ray and /or a CT evidence of a pneumoperitoneum. The conservative management consisted of IV fluids, intravenous antibiotics (Cefotoxime and Metronidazole) and IV Omeprezole. Ryle’s tube no 18 was used to empty the stomach by constant suction. An accurate tube placement in the distal greater curvature is crucial. A strict input-output chart, a two hourly pulse rate, the blood pressure(BP) and the temperature were recorded. The abdomen was examined frequently for distension, tenderness and bowel sounds. For the first 2-3 days, absolutely nothing was given by mouth. For the first 4-5 days, the senior surgeon examined the cases 2-3 times daily. The conservative treatment was discontinued if the patient failed to improve or if he/she deteriorated (increasing pulse rate, pyrexia, abdominal distension or pain) after 12 hours of the treatment. Clear fluids were started on the 4th to 5th day, with the nasogastric tube being blocked. The patients were carefully watched for signs of peritonitis. If they tolerated well, the nasogastric tube was removed and liquid feeds were started. A majority of the patients were discharged 10-15 days later, with anti-ulcer and anti-H. pylori treatment. An upper GIT endoscopy after 1 month was advised.

Results

During the study period, we had 113 cases of perforated peptic ulcer cases. 63 cases were excluded from the study (22 cases were not willing to take the non-operative treatment and the remaining 41 cases didn’t fulfill our inclusion criteria). The clinical details of the selected 50 cases are shown in (Table/Fig 1) and (Table/Fig 2).

41 of the 50 cases responded well to the conservative non-operative treatment, while the remaining 9 cases failed to improve and they required emergency laparotomy. Hence, the success rate of the non-operative management of perforated peptic ulcer in our study was 82% (Table/Fig 3).

All the 9 patients who failed to improve after the 12 hours trial and underwent laparotomy had unsealed perforations. 7 were duodenal and 2 were benign gastric perforations. There were no significant differences between the failure group and the successful group with regards to the age, duration of the perforation before presentation and the hospital stay (Table/Fig 4). 11 patients in the successful group and 2 in the failed group had complications (Table/Fig 5). All the 4 cases with peritoneal abscesseswere drained successfully by percutaneous needle aspiration under USG guidance and they recovered without any sequelae. Other complications were managed medically and they didn’t prolong the hospital stay.

Follow up
Out of 41 cases in successful group, 9 cases didn’t turn up for the follow up. The remaining 32 cases were followed up for about 1 year. All these 32 cases received the anti-ulcer treatment. 25 cases also received the anti-H pylori treatment, who had tested positive for the H.pylori infection. None of them required a definitive surgery for peptic ulcer. 26 of the 32 cases were subjected to upper GIT endoscopy, 1 month after the perforation (Table/Fig 6), while the remaining 6 cases were not willing to undergo endoscopy. Among the 9 cases in the failed group, 3 didn’t show up for follow up. The remaining 6 cases underwent endoscopy and they also received anti-H.pylori treatment (Table/Fig 6).

Discussion

Perforation is one of the dreaded complications of peptic ulcers. Until recently, surgical closure of the perforation has remained the unchallenged treatment of choice (8). Recently, a conservative non-surgical treatment for perforated peptic ulcer has drawn much attention.

The earliest report of the recovery of a perforated peptic ulcer without a surgical treatment was recorded in I870 by Redwood (9). In 1935, Wangensteen noted that ulcers were able to self seal and he reported on seven cases which were treated without surgery. In 1946, this observation was confirmed by Taylor and he treated 28 cases without surgery, with good success. In 2004, Songne et al (10), in his study, reported that more than 50% of the patients with perforated peptic ulcers responded to the conservative treatment without surgery (11). The rationale behind the conservative management is (8): • Peritonitis per se is no longer the killer as it used to be. Because, with the aid of the newer armamentarium at our disposal, the peritoneum will localize usually and absorb the contaminant. • In gastroduodenal perforation, the peritoneal cavity usually remains sterile for 12 hours because the bacterial load is low in the upper gastrointestinal tract (12) and • Most of the times, after opening the peritoneal cavity for the surgical treatment of perforated peptic ulcers, it is frequently observed that the perforation has already been sealed by the omental plug and the undersurface of the liver (8),(12),(13). Concern over the peritoneal soilage has led the surgeons to believe that it is important to carefully empty and wash out the peritoneal cavity with a large volume of normal saline at the time of the operation (11). However, the actual benefit of this part of the operation is not very clear. Rosoff reported that out of 109 patients who were treated non-operatively, only 3 had developed intra-abdominal abscesses (11). Though there has also been concern about the releakage of the ulcer, this has been a very unusual occurrence (11). In the studies which were done by Berne and Rosoff, this occurred in only 2 of the 109 patients who were treated non-operatively. One of the major concerns with the conservative management is the risk of a misdiagnosis. However, as Taylor has shown, with a regular re-assessment, the misdiagnosis will become rapidly apparent and the conservative treatment can then be discontinued (11). Taylor reported no serious consequences which resulted from the short delay in making the diagnosis (5). Irvin (13) identified the risk factors, which included, age over 70 years, the use of steroidal or nonsteroidal anti-inflammatory drugs, concomitant medical illnesses and the presence of shock (11).

Outline of the Treatment
These cases should be supervised by a surgeon who has got experi-ence in the management of patients with peritonitis. The surgeon should examine these patients at least every four hours during the first two days of this treatment (8). The non-operative treatment of perforated peptic ulcers cannot be handled casually (8). Absolutely nothing is given by mouth (8). Careful positioning of the nasogastric tube in the distal part of the greater curvature and nasogastric suction are the most important elements in the conservative treatment which keeps the stomach empty, allowing the sealing of the perforation to take place (8),(11). Strict input and output charts should be maintained. Intravenous antibiotics and H2 blockers or proton pump inhibitors should also be given. It is crucial to monitor the pulse rate, the BP and the temperature. The abdomen should be examined frequently for tenderness, rigidity and bowel sounds. The rigidity regressesrapidly, disappearing from below upwards, and it is usually gone within 24 to 48 hours (8). In the more recent publications, the morbidity and the mortality rates of the conservative treatment have been reported to be between 0%-8%, while those of the emergency surgical ulcer closure are currently in the range of 3–9% (3), (10), (14),(15),(16),(17),(18),(19). Despite this data, the conservative treatment of perforated peptic ulcers has not gained widespread acceptance and it remains controversial. The reason may be the need of a prudent clinical monitoring by an experienced surgeon and the fear of a misdiagnosis (19), (20). When a policy of a non-operative management is adopted, it is important to perform a follow-up endoscopy to monitor the ulcer healing, treat it for H. pylori, and to provide an accurate diagnosis. The most common complication of a non-operative management is peritoneal abscess formation. Fortunately, most of the abscesses can be treated with antibiotics and/or percutaneous drainage without any sequelae (3), (21), (22).

Conclusion

We conclude that the conservative treatment of perforated peptic ulcers is effective and that it is a safe alternative in selected cases, provided a strict inclusion criteria and guidelines are followed.

Acknowledgement

We would like to thank all the consultant surgeons at the AJ Institute of Medical Sciences, Mangalore, for allowing us to analyze their cases. The authors confirm that there are no known conflicts of interest which are associated with this publication and that there has been no financial support for this work that could have influenced its outcome.

References

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Han-Wen Chang, Wai-Mau Choi. Nonoperative Treatment of Perforated Duodenal Ulcer: A Case Report and Review of the Literature. J Emerg Crit Care Med 2007; 18(4).
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Wangensteen O. Non-operative treatment of localized perforations of the duodenum. Minn Med. 1935; 18:477.
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Crofts T, Park K, Steele R. A randomized trial of nonoperative treatment for perforated peptic ulcer. N Engl J Med.1989; 320:970–73.
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Taylor H. Perforated peptic ulcer treated without operation. Lancet. 1946;2:441–44.
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Major Harold F, Bertram. Nonoperative treatment of perforated duodenal ulcer- Preliminary report of 16 consecutive cases with no mortality. Annals of Surgery December, 1950
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Pascal bucher, Wassila oulhaci, Philippe morel, Frederic ris, Olivier huber. Results of conservative treatment for perforated gastroduodenal ulcer in patients not eligible for surgical repair. Swiss med wkly 2007;137:337–340.
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Irvin T. Mortality and perforated peptic ulcer: case for risk stratification in elderly patients. Br J Surg 1989; 76: 215-8.
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Keane TE, Dillon B, Afdhal NH, McCormack CJ. Conservative management of perforated duodenal ulcer. Br J Surg 1988; 75: 583-4
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Giacchi R, Fattori A, De Poda D. A conservative Taylor’s method in the treatment of peptic perforation. G Chir. 1990; 11: 640–42.
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Steeley S, Campbell D. Nonoperative treatment of perforated duodenal ulcer: a further report. Surg Gynecol Obstet. 1956;102:435–46.
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Leconte D, Hiebel G. La méthode de Taylor dans le traitement des ulcères gastro-duodenaux perforés: est-elle vraiment désuète? Ann Gastroenterol Hepatol 1986; 22:261–66.
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