Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Dr Archana Dambal

"Journal of clinical and diagnostic research is a welcome change in publishing practices. It aims to reach out to the grass-root level researchers who do not lack in experience, clinical material and ideas, but lack in their knowledge in English language and statistics. The journal achieves it's aim by supporting in these exact domains.
It also gives due credit to all research designs like descriptive and qualitative studies while many journals ignore these important study designs. The rigorous review process does not allow any compromise in quality
It is indexed in many indexing agencies and the articles are available under creative commons licence free of cost
The frequency of publication supports many aspiring authors from India and other countries.
It's wide scope welcomes articles across various specialities in medicine. In an era when there is an unscientific insistence on speciality specific research by regulatory bodies in medical education, JCDR supports collaborative research across specialities. I wish the publisher all the best in his future endeavors."



Dr. Archana Dambal
Department of General Medicine,
Belgaum Institute of Medical Sciences,Belgaum, Karnataka,INDIA,
On 30 Nov 2018




Dr Bhanu K Bhakhri

"The Journal of Clinical and Diagnostic Research (JCDR) has been in operation since almost a decade. It has contributed a huge number of peer reviewed articles, across a spectrum of medical disciplines, to the medical literature.
Its wide based indexing and open access publications attracts many authors as well as readers
For authors, the manuscripts can be uploaded online through an easily navigable portal, on other hand, reviewers appreciate the systematic handling of all manuscripts. The way JCDR has emerged as an effective medium for publishing wide array of observations in Indian context, I wish the editorial team success in their endeavour"



Dr Bhanu K Bhakhri
Faculty, Pediatric Medicine
Super Speciality Paediatric Hospital and Post Graduate Teaching Institute, Noida
On Sep 2018




Dr Mohan Z Mani

"Thank you very much for having published my article in record time.I would like to compliment you and your entire staff for your promptness, courtesy, and willingness to be customer friendly, which is quite unusual.I was given your reference by a colleague in pathology,and was able to directly phone your editorial office for clarifications.I would particularly like to thank the publication managers and the Assistant Editor who were following up my article. I would also like to thank you for adjusting the money I paid initially into payment for my modified article,and refunding the balance.
I wish all success to your journal and look forward to sending you any suitable similar article in future"



Dr Mohan Z Mani,
Professor & Head,
Department of Dematolgy,
Believers Church Medical College,
Thiruvalla, Kerala
On Sep 2018




Prof. Somashekhar Nimbalkar

"Over the last few years, we have published our research regularly in Journal of Clinical and Diagnostic Research. Having published in more than 20 high impact journals over the last five years including several high impact ones and reviewing articles for even more journals across my fields of interest, we value our published work in JCDR for their high standards in publishing scientific articles. The ease of submission, the rapid reviews in under a month, the high quality of their reviewers and keen attention to the final process of proofs and publication, ensure that there are no mistakes in the final article. We have been asked clarifications on several occasions and have been happy to provide them and it exemplifies the commitment to quality of the team at JCDR."



Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
Ex-President - National Neonatology Forum Gujarat State Chapter
Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018




Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



Dr Kalyani R
Professor and Head
Department of Pathology
Sri Devaraj Urs Medical College
Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
On Sep 2018




Dr. Saumya Navit

"As a peer-reviewed journal, the Journal of Clinical and Diagnostic Research provides an opportunity to researchers, scientists and budding professionals to explore the developments in the field of medicine and dentistry and their varied specialities, thus extending our view on biological diversities of living species in relation to medicine.
‘Knowledge is treasure of a wise man.’ The free access of this journal provides an immense scope of learning for the both the old and the young in field of medicine and dentistry as well. The multidisciplinary nature of the journal makes it a better platform to absorb all that is being researched and developed. The publication process is systematic and professional. Online submission, publication and peer reviewing makes it a user-friendly journal.
As an experienced dentist and an academician, I proudly recommend this journal to the dental fraternity as a good quality open access platform for rapid communication of their cutting-edge research progress and discovery.
I wish JCDR a great success and I hope that journal will soar higher with the passing time."



Dr Saumya Navit
Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
Lucknow
On Sep 2018




Dr. Arunava Biswas

"My sincere attachment with JCDR as an author as well as reviewer is a learning experience . Their systematic approach in publication of article in various categories is really praiseworthy.
Their prompt and timely response to review's query and the manner in which they have set the reviewing process helps in extracting the best possible scientific writings for publication.
It's a honour and pride to be a part of the JCDR team. My very best wishes to JCDR and hope it will sparkle up above the sky as a high indexed journal in near future."



Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata




Dr. C.S. Ramesh Babu
" Journal of Clinical and Diagnostic Research (JCDR) is a multi-specialty medical and dental journal publishing high quality research articles in almost all branches of medicine. The quality of printing of figures and tables is excellent and comparable to any International journal. An added advantage is nominal publication charges and monthly issue of the journal and more chances of an article being accepted for publication. Moreover being a multi-specialty journal an article concerning a particular specialty has a wider reach of readers of other related specialties also. As an author and reviewer for several years I find this Journal most suitable and highly recommend this Journal."
Best regards,
C.S. Ramesh Babu,
Associate Professor of Anatomy,
Muzaffarnagar Medical College,
Muzaffarnagar.
On Aug 2018




Dr. Arundhathi. S
"Journal of Clinical and Diagnostic Research (JCDR) is a reputed peer reviewed journal and is constantly involved in publishing high quality research articles related to medicine. Its been a great pleasure to be associated with this esteemed journal as a reviewer and as an author for a couple of years. The editorial board consists of many dedicated and reputed experts as its members and they are doing an appreciable work in guiding budding researchers. JCDR is doing a commendable job in scientific research by promoting excellent quality research & review articles and case reports & series. The reviewers provide appropriate suggestions that improve the quality of articles. I strongly recommend my fraternity to encourage JCDR by contributing their valuable research work in this widely accepted, user friendly journal. I hope my collaboration with JCDR will continue for a long time".



Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011

Important Notice

Case report
Year : 2011 | Month : November | Volume : 5 | Issue : 7 | Page : 1464 - 1466

Primary B Cell Non-Hodgkin’s Lymphoma Presenting With Multiple Osteolytic Bony Lesions In Skull

Maya Patil, Shilpa Aditya Pratinidhi, Ajay Malik, Rachana Gulati, Avinash R Joshi

1. MD, Assistant Professor, Dept of Paediatrics, Smt Kashibai Navale Medical College, Pune. 2. MD, Associate Professor, Dept of Biochemistry, Smt Kashibai Navale Medical College, Pune. 3. MD, Assoc Professor, Dept of Pathology, Armed Forces Medical College, Pune. 4. DCP, Assistant Lecturer, Dept of Pathology, Smt Kashibai Navale Medical College, Pune. 5. MD, Professor and Head, Dept of Pathology, Smt Kashibai Navale Medical College, Pune.

Correspondence Address :
Maya Patil, Assistant Professor,
Dept of Paediatrics, Smt Kashibai Navale Medical College,
Pune - 411041, Maharashtra, India.
Phone: 91-20-24106125,9890192458.
E-mail: mayashilpa5@gmail.com

Abstract

Background: Head and neck is a common site of extra-nodal NHL. However primary bony NHL is a rare presentation of an extranodal NHL. We are presenting a rare and a typical case of primary lymphoma of bone in a six year old male child presenting as low back ache, fever and difficulty in walking since two months. He had multiple osteolytic lesions in skull. Vertebral transpedicle biopsy revealed B cell lymphoma with morphologic and immunophenotypic features of immunoblastic type.

Discussion & Conclusion: We discussed NHL with an emphasis on extranodal bony manifestations. Primary bone NHL has a favorable outcome when treated with a combined modality therapy and regular follow up. To the best of our knowledge, this is one of the rare primary NHL of the bone being reported in the Indian literature.

Keywords

NHL, Osteolytic lesion, Transpedicular biopsy, Immunohistochemistry

How to cite this article :

Maya Patil, Shilpa Aditya Pratinidhi, Ajay Malik, Rachana Gulati, Avinash R Joshi. PRIMARY B CELL NON-HODGKIN’S LYMPHOMA PRESENTING WITH MULTIPLE OSTEOLYTIC BONY LESIONS IN SKULL. Journal of Clinical and Diagnostic Research [serial online] 2011 November [cited: 2019 Aug 17 ]; 5:1464-1466. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2011&month=November&volume=5&issue=7&page=1464-1466&id=1701

Introduction
Lymphomas are the third most common group of cancers in children and adolescents (1). Non-Hodgkin’s lymphomas (NHL) represent approximately 60 percent of these and Hodgkin’s lymphoma account for the remainder. NHL are categorised as low, intermediate and high grade on the basis of aggressiveness. NHL only rarely present as a primary osseous lesions (2). Clinical presentation in children is varied and depends upon the histologic subtype, the extent of the disease and primary site of the tumour. Children typically have extranodal disease involving the mediastinum, abdomen, or the head and neck region. Up to 40 percent of these are extra nodal (2),(3),(5),(7). Most primary lymphomas of the bone, are classified as diffuse large B cell lymphomas (DLBCL) (5).

Histopathology diagnosis of NHL is not always easy as in childhood most malignant tumours other than lymphomas are composed of small cells that appear undifferentiated. There is a definitive role of immunohistochemistry in these tumours (7). High grade NHL comprise three histologic subtypes mainly, small non-cleaved, lymphoblastic and the large cell lymphoma (2),(3),(8),(9). DLBCL in children are relatively rare as they represent less than five percent of NHL. In our case, the child presented with bone involvement in the form of bone pains not relieved by rest, a palpable soft tissue mass, and systemic B symptoms but no lymphadenopathy. He was diagnosed as Primary lymphoma of bone (PLB). We are reporting a unique case for its rarity (Primary NHL of bone -diffuse large B cell lymphoma). In the paediatric population, it represents approximately three to nine percent of NHL cases (10).

Case Report

A six year old male child was admitted in our hospital with complaints of difficulty in walking since two months, low back pain for 15 days along with fever. At admission, patient was febrile with a temperature of 38°c, heart rate of 120 per minute, BP 90/66 mmHg and weighed 15 Kg. Scoliosis was noted at T12–L4 level and diffuse tenderness was present at thoraco-lumbar spine. There was no organomegaly or any significant lymphadenopathy. Bladder and bowel control was intact. Other systems were normal including fundus examination. X ray and MRI Spine was done on day 2 of admission which showed lesions suspicious of infective pathology in second lumbar vertebral region. Skull X ray revealed multiple osteolytic punched out lesions (Table/Fig 1). Over the course of next ten days, the patient gradually developed hyperreflexia.

In view of spinal tenderness and lytic lesions in the skull, a bone marrow aspiration and biopsy was done. Bone marrow aspirate and biopsy was reactive in nature. The CT scan report showed multiple lytic lesions in vertebral bodies, bilateral pelvic bones, and upper part of femur with an impression of a leukaemic or metastatic disease. CT guided vertebral transpedicle biopsy was done at L2-L3 region. The biopsy specimen was subjected to a panel of immunohistochemical markers – CD3, CD20, CD45, CD10 and BCL 6. The tumor cells were diffusely positive for CD45, CD20 and CD10 with scattered CD3 positive T cells. Bcl6 was negative (Table/Fig 2) (A to F)].

Based on the morphology and immunochemical features a diagnosis of DLBCL immunoblastic variant arising from follicularcentre cells was offered. Patient was sent to Tata memorial centre for further management.

Discussion

NHL only rarely present as a primary osseous lesions. PLB is defined as a lymphoma that is confined to the bone or bone marrow. It comprises approximately three to seven percent of all extra-nodal NHL and seven percent of Primary bone tumour (1),(2),(3),(4),(5),(6),(7),(8),(9),(10). As primary lymphoma of bone is a highly curable disease, differentiation from other causes of lytic bone lesions such as secondaries from carcinomas and other tumours is important. The child was admitted in the ward with the complaints pertaining to bone involvement. He had difficulty in walking since last two months, low back pain along with fever and diffuse tenderness over the back. All these changes indicate the presence of the disease which was indolent (11). PLB can present in both adult as well as paediatric population but, with different prognosis, thus both are a separate entities. The majority of cases of DLBCL are primary but, it can also arise by transformation of B-CLL /SLL, lymphoplasmacytic lymphoma, follicular lymphoma, MALT lymphoma and lymphamatoid granulamatosus (14). The diagnosis can be made by Fine needleaspiration cytology (FNAC) or biopsy or by examination of bone marrow. Immunohistochemistry helps to make accurate diagnosis. Macroscopically, DLBCL usually forms a distinct tumour mass at extra nodal site. Microscopically, the commonest subtypes of PLB are B cell lymphomas with diffuse mixed cell or diffuse large cell histology. Sheets of large monomorphic lymphoid cells with one or more prominent nucleoli and a distinct rim of cytoplasm are usually noticed in DLBCL. CD 19, CD20, CD22 and surface immunoglobulins as seen in immunophenotyping are present in DLBCL (7). The International prognostic index (IPI) has been shown to be useful a prognostic tool for predicting the behavior of the disease in NHL (13). Elevated serum LDH or higher modified stages are associated with a trend toward poorer overall survival among children with CNS disease as seen by Sandlund et al (14). Molecular profiling of DLBCL by various methods and to varying degrees may help separate DLBCL cases into different prognostic relevant groups and allow them to be treated accordingly (15).

Conclusion

A greater tumour burden at diagnosis adversely influences the treatment outcome of children with NHL and CNS disease at diagnosis, suggesting a need for ongoing improvement in both systemic and CNS-directed therapy. DLBCL should be differentiated from other lymphomas and other malignancies morphologically in most cases. Immunohistochemical stains are of great help with the subtyping of NHL after morphological diagnosis. We also conclude that Transpedicular biopsy is an excellent tool to diagnose Primary lymphoma of bone in difficult cases.

Key Message

Physician dealing with bone, back pain in children should also consider and exclude the possibility of haematological malignancy in those children who are not responding to conventional treatment.

References

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Sandlund JT, Downing JR, Crist WM. Non-Hodgkin’s lymphoma in childhood. New Eng J of Med 1996; 331:1238-43.
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Tong M, Yau TK, Wu WC, Lam JJ, Lee AWM. Primary Non-Hodgkin’s lymphoma of bone: a rare cause of lytic bone lesion. JHK coll Radiol 2004; 7: 24-30.
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Thakur JS, Minhas RS, Mohindroo NK, Sharma DR, Mohindroo S, Thakur A, et al. Primary non-Hodgkin’s lymphoma of the infratemporal fossa: a rare case report. Head & Neck Oncol 2009; I:20.
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De Camargo OP, dos Santos Machado TM, Croci AT, et al. Primary bone lymphoma in 24 patients treated between 1955 and 1999. Clin Orthop 2002; 397:271-80.
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Kitsoulis P, Vlychou M, Papoudou-Bai A. Primary lymphoma of the bone. Anticancer Res 2006; 26(1A):325-37.
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Stokes SH, Walz BJ. Pathological fracture after radiation therapy for primary non-Hodgkin’s malignant lymphoma of bone. Int J Radiation Oncol Biol Phys 1983; 9:1153-59.
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Döll C, Wulff B, Rössler J, Schaper J, Havers W. Primary B cell lymphoma of bone in children. Eur J Paediatr 2001; 160(4):239-42.
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Murphy SB, Fairdough DL, Hutchison RE, Berard CW. Non-Hodgkin’s lymphomas of childhood: An analysis of histology, staging and response to treatment of 338 cases at a single institution. J Clin Oncol 1989; 7:186-93.
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Zhao XF, Young KH, Dale F. Paediatric primary bone lymphoma–Diffuse large B-cell lymphoma. Morphologic and immunohistochemical characteristics of 10 Cases. Am J Clin Pathol 2007; 127:47-54.
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Baar J, Burkes RL, Gospodarowicz M. Primary Non-Hodgkin’s lymphoma of bone. Semin Oncol 1999; 26:270-5.
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Wong KF, Chan JK, Ng CS. Large cell lymphoma with initial presentation in the bone marrow. Hematol Oncol 1992; 10:261-71.
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Pileri SA, Dirnhofer S, Went P, Ascani S, Sabattini E, Marafioti T, et al. Diffuse large B-cell lymphoma: one or more entities? Present controversies and possible tools for its subclassification. Histopathology 2002; 41:482-509.
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Dubey P, Ha CS, Besa PC. Localized primary malignant lymphoma of bone. Int J Radiation Oncol Biol Phys 1997; 37: 1087-93.
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Sandlund JT, Murphy SB, Santana VM, Behm F, Jones D, Berard CW, et al .CNS Involvement in Children with newly diagnosed non- Hodgkin’s lymphoma. J Clin Oncol 2000;18(16): 3018-24.
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Youjun Hu, Yang K, Krause JR. Review Diffuse Large B-cell Lymphoma, Differential Diagnosis and Molecular Stratification. N A J Med Sci 2011; 4 (2):67-76.

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