Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Dr Archana Dambal

"Journal of clinical and diagnostic research is a welcome change in publishing practices. It aims to reach out to the grass-root level researchers who do not lack in experience, clinical material and ideas, but lack in their knowledge in English language and statistics. The journal achieves it's aim by supporting in these exact domains.
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Dr. Archana Dambal
Department of General Medicine,
Belgaum Institute of Medical Sciences,Belgaum, Karnataka,INDIA,
On 30 Nov 2018




Dr Bhanu K Bhakhri

"The Journal of Clinical and Diagnostic Research (JCDR) has been in operation since almost a decade. It has contributed a huge number of peer reviewed articles, across a spectrum of medical disciplines, to the medical literature.
Its wide based indexing and open access publications attracts many authors as well as readers
For authors, the manuscripts can be uploaded online through an easily navigable portal, on other hand, reviewers appreciate the systematic handling of all manuscripts. The way JCDR has emerged as an effective medium for publishing wide array of observations in Indian context, I wish the editorial team success in their endeavour"



Dr Bhanu K Bhakhri
Faculty, Pediatric Medicine
Super Speciality Paediatric Hospital and Post Graduate Teaching Institute, Noida
On Sep 2018




Dr Mohan Z Mani

"Thank you very much for having published my article in record time.I would like to compliment you and your entire staff for your promptness, courtesy, and willingness to be customer friendly, which is quite unusual.I was given your reference by a colleague in pathology,and was able to directly phone your editorial office for clarifications.I would particularly like to thank the publication managers and the Assistant Editor who were following up my article. I would also like to thank you for adjusting the money I paid initially into payment for my modified article,and refunding the balance.
I wish all success to your journal and look forward to sending you any suitable similar article in future"



Dr Mohan Z Mani,
Professor & Head,
Department of Dematolgy,
Believers Church Medical College,
Thiruvalla, Kerala
On Sep 2018




Prof. Somashekhar Nimbalkar

"Over the last few years, we have published our research regularly in Journal of Clinical and Diagnostic Research. Having published in more than 20 high impact journals over the last five years including several high impact ones and reviewing articles for even more journals across my fields of interest, we value our published work in JCDR for their high standards in publishing scientific articles. The ease of submission, the rapid reviews in under a month, the high quality of their reviewers and keen attention to the final process of proofs and publication, ensure that there are no mistakes in the final article. We have been asked clarifications on several occasions and have been happy to provide them and it exemplifies the commitment to quality of the team at JCDR."



Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
Ex-President - National Neonatology Forum Gujarat State Chapter
Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018




Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



Dr Kalyani R
Professor and Head
Department of Pathology
Sri Devaraj Urs Medical College
Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
On Sep 2018




Dr. Saumya Navit

"As a peer-reviewed journal, the Journal of Clinical and Diagnostic Research provides an opportunity to researchers, scientists and budding professionals to explore the developments in the field of medicine and dentistry and their varied specialities, thus extending our view on biological diversities of living species in relation to medicine.
‘Knowledge is treasure of a wise man.’ The free access of this journal provides an immense scope of learning for the both the old and the young in field of medicine and dentistry as well. The multidisciplinary nature of the journal makes it a better platform to absorb all that is being researched and developed. The publication process is systematic and professional. Online submission, publication and peer reviewing makes it a user-friendly journal.
As an experienced dentist and an academician, I proudly recommend this journal to the dental fraternity as a good quality open access platform for rapid communication of their cutting-edge research progress and discovery.
I wish JCDR a great success and I hope that journal will soar higher with the passing time."



Dr Saumya Navit
Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
Lucknow
On Sep 2018




Dr. Arunava Biswas

"My sincere attachment with JCDR as an author as well as reviewer is a learning experience . Their systematic approach in publication of article in various categories is really praiseworthy.
Their prompt and timely response to review's query and the manner in which they have set the reviewing process helps in extracting the best possible scientific writings for publication.
It's a honour and pride to be a part of the JCDR team. My very best wishes to JCDR and hope it will sparkle up above the sky as a high indexed journal in near future."



Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata




Dr. C.S. Ramesh Babu
" Journal of Clinical and Diagnostic Research (JCDR) is a multi-specialty medical and dental journal publishing high quality research articles in almost all branches of medicine. The quality of printing of figures and tables is excellent and comparable to any International journal. An added advantage is nominal publication charges and monthly issue of the journal and more chances of an article being accepted for publication. Moreover being a multi-specialty journal an article concerning a particular specialty has a wider reach of readers of other related specialties also. As an author and reviewer for several years I find this Journal most suitable and highly recommend this Journal."
Best regards,
C.S. Ramesh Babu,
Associate Professor of Anatomy,
Muzaffarnagar Medical College,
Muzaffarnagar.
On Aug 2018




Dr. Arundhathi. S
"Journal of Clinical and Diagnostic Research (JCDR) is a reputed peer reviewed journal and is constantly involved in publishing high quality research articles related to medicine. Its been a great pleasure to be associated with this esteemed journal as a reviewer and as an author for a couple of years. The editorial board consists of many dedicated and reputed experts as its members and they are doing an appreciable work in guiding budding researchers. JCDR is doing a commendable job in scientific research by promoting excellent quality research & review articles and case reports & series. The reviewers provide appropriate suggestions that improve the quality of articles. I strongly recommend my fraternity to encourage JCDR by contributing their valuable research work in this widely accepted, user friendly journal. I hope my collaboration with JCDR will continue for a long time".



Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011

Important Notice

Case report
Year : 2007 | Month : December | Volume : 1 | Issue : 6 | Page : 537 - 539

Puvasol Induced Bullous Pemphigoid In A Case Of Psoriasis

KUMAR P, JAIN R K, SHARMA P K, KAR H K Correspondence Address :
Dr. Pramod Kumar, Post box-17, P.C. 319. Sultanate of Oman. Email:kumarpramod5@rediff.com

Abstract

Psoriasis is a chronic scaly disease of unknown aetiology. There are many theories for its causation and similarly there is no cure for it. There are multiple therapies for its treatment yet the results are different for different patients. A 60-years-old male suffering from Psoriasis for decades developed Bullous Pemphigoid after the initiation of PUVASOL therapy

Keywords

Psoriasis, Bullous Pemphigoid, Puvasol

How to cite this article :

KUMAR P,JAIN RK,SHARMA PK,KAR HK. PUVASOL INDUCED BULLOUS PEMPHIGOID IN A CASE OF PSORIASIS. Journal of Clinical and Diagnostic Research [serial online] 2007 December [cited: 2019 Aug 23 ]; 1:537-539. Available from
http://www.jcdr.net/back_issues.asp?issn=0973-709x&year=2007&month=December&volume=1&issue=6&page=537-539&id=163

Psoriasis is a chronic papulosquamous disorder. Seborrheic dermatitis, lichen simplex chronicus and lichen planus may co-exist or alternate with psoriasis. Other reported cutaneous associations include Pemphigoid, Neurofibromatosis, Actinic reticuloid, Peutz-Jeghers syndrome, Vitiligo, Lupus erythematosus, and viral warts.(1)

Bullous pemphigoid (BP) was apparently precipitated in many cases by therapy for psoriasis viz. PUVA, UVL and tar, UVL and anthralene.(2)

Association of Pemphigus and Hailey-Hailey disease(3), Linear IgA bullous dermatosis(4) and Epidermolysis bullosa acquisita(5) has also been reported.

We report a case of psoriasis who developed BP following Puvasol therapy and discuss the various views on pathogenesis of bullous disorders in psoriasis patients. This report highlights the importance to be aware of adverse effects of commonly use medications (Methoxypsoralen), which even a GP would prescribe.

Case Report

A 60-year-old male, suffering from psoriasis presented with blisters all over the body for one month. The patient was apparently well 16 years ago when he was diagnosed as suffering from psoriasis for his scaly skin patches. He underwent various treatment plans since, including local application of coal tar, dithranol and even oral methotrexate with remissions and relapses as is usual with psoriasis.

The patient had been receiving 20 mg of 8-methoxypsoralen followed by sun-exposure for nearly two weeks when he developed vesiculobullous lesions on the anterior abdominal wall which later spread all over the body in a period of one week.

On cutaneous examination the patient had multiple well-defined erythematous plaques with micaceous scaling on extensor aspect of upper and lower limbs, anterior abdominal wall, lumbosacral region (Table/Fig 1) and scalp. Auspitz sign was positive in these plaques. Multiple discrete bullae were also present on abdominal wall, back, upper and lower limbs(Table/Fig 2). The bullae were tense and bulla spreading sign was positive, however Nikolsky’s sign was negative. Scalp, face, mucous membranes, palms, soles and nails were spared. On per rectal examination prostate was found to be normal in size and consistency.

Blood sugar, urea, liver function tests, kidney function tests and acid phosphatase levels were within the normal limits. His Hemoglobin was 10.9 gm percent, total leucocyte count as 10,200 per cu mm. Polymorphs were 68 percent, lymphocytes 30 per cent, eosinophils 2 per cent. Erythrocyte sedimentation rate was 20 mm in first hour. Stool examination for occult blood and urine examination were normal. VDRL was non-reactive. Skiagram of chest and Ultra sonogram of abdomen were normal.

Tzanck’s preparation did not show acantholytic cells, instead eosinophils were present. Skin biopsies from bullous and scaly lesions were consistent with sub epidermal split with eosinophilic infiltrate and psoriasis respectively. Electron microscopy and direct
immunoflouroscence from perilesional skin around bullae confirmed the diagnosis of BP.

The patient was put on oral antibiotics and prednisolone along with supportive therapy. The plaques and bullae started resolving from the 6th day of the institution of treatment and resolved completely within two weeks. Prednisolone was tapered off over a period of 4 weeks under the cover of methotrexate 15 mg once a week in 3 divided doses.

Discussion

The association between psoriasis and BP may be more than coincidental. Grattan(6) reported an increased incidence of psoriasis in BP patients unrelated to therapy in a retrospective case control study, he reviewed 62 cases of BP, most confirmed by immunopathology; and 62 cases of leg ulcers as controls. He found that psoriasis occurred in 11 per cent of BP cases and in none of the controls.

Carla(7) reported a case of Pemphigus herpetiformis in a patient with psoriasis who was receiving UVB therapy.

The exact role of UV light in the induction of BP is unknown. It is quite a possibility that intense UV light therapy may induce alteration of normal human structures creating antigens to which the host responds with auto antibodies. It is thought that the blisters may arise as a result of immunological response of the host against UV altered basement membrane zone (BMZ)(2).

Changes at the BMZ in psoriasis may be responsible for heterogenous antibody response and may trigger the bullous disease, as may antipsoriatic treatment, including tar and UV radiation. However, common immunogenetic mechanisms may play a crucial part in this disease association.(8)

A term “psoriasis bullosa acquisita” was suggested for patients with circulating auto antibody targeted against a skin component closely associated with type VII collagen.(9)

Although BP has been reported to be induced by sun exposure in one case(3), it could not be ascertained whether our patient developed BP as a result of insult by sun exposure or sun exposure combined with oral psoralen therapy. The cases described earlier had psoriasis for decades prior to onset of BP(3)and so did our patient who had psoriasis for 16 years and was undergoing PUVASOL therapy when he developed BP.

Possibilities of malignancy or any other vesiculobullous disorder in this patient were ruled out by ultrasonography, histopathology and electron microscopy respectively.

This case is being reported due to the rare coincidence of psoriasis and BP. with all probability precipitated by PUVA-SOL therapy; and to the best of our knowledge there has not been any report of such a case from India so far. Methoxypsoralen combined with solar ultraviolet light is commonly used therapy in India where there is lot of Sunlight all time round the year, this case highlights the fact that we should be prepared to see these kind of side effects with PUVASOL therapy, however rare it may be.

References

1.
R D R Camp. Psoriasis; In Champion Rh, Burton Jl and Ebling Fjg editorss, Textbook of Dermatology 5th ed, Oxford(England), Blackwell scientific publications 1991;1391-1458.
2.
Robinson J K, Baughman R D and Provost T T.Bullous Pemphigoid induced by PUVA therapy. Brit J Dermatol 1978;99:709-713.
3.
Graunwald MH, David M and Feuerman EJ. Coexistence of Psoriasis vulgaris and bullous diseases. J Am Acad Dermatol 1985;13:224-228.
4.
TakagI Y, Sawada S, Yamauchi M, Amagai M and Nimura M. Coexistence of Psoriasis and Linear IgA bullous Dermatosis. Brit J Dermatol 2000; 142(3):513-516.
5.
Endo Y, Tamura A, Ishikawa O, Miyachi Y and Hashimito J. Psoriasis vulgaris coexistent with Epidermolysis bullosa acquisita. Brit J Dermatol 1997;137(5):783-786.
6.
Grattan CEH. Evidence of an association between bullous pemphigoid and Psoriasis. Brit J Dermatol 1985;113:281.
7.
Carla Sanchez-Palacios and Lawrence S. Chan. Development of Pemphigus herpetiformis in a patient with psoriasis receiving UV-light treatment. J Cut Path 2004;31(4):346-349.
8.
Kirtschig G, Chow E T Y, Venning Va and Wojnarowska FT. Acquired sub epidermal bullous diseases associated with psoriasis: a clinical, immunopathological and immunogenetic study. Brit J Dermatol 1996;135(5):738-745.
9.
Morris Sd, Malipeddi R, Oyama N, Gratian MJ, Harman KE, Bhogal BS et al. Clinical dermatology: Concise report Psoriasis bullosa acquisita. Clin Exp Dermatol 2002;27(8):65-669.

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