Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
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Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."

Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Original article / research
Year : 2007 | Month : April | Volume : 1 | Issue : 2 | Page : 50 - 54 Full Version

Evaluation Of The Cellular Immune Response In Patients With Head And Neck Cancer

Published: April 1, 2007 | DOI:

Firat University Medical Faculty Dept. of Immunology and Firat University Medical Faculty Dept. of ENT Diseases

Correspondence Address :
Firat University Department of Immunology.
Phone:+90 424 2333555/2166, Email: fulhan23@yahoo.


Aim: The aim of the present study is to evaluate the cellular immune response in patients with head and neck cancer.
Material-Method: Twenty volunteer healthy subjects as controls and 34 patients who have been diagnosed with squamous cell carcinoma at the Department of Ear Nose Throat in Firat University Firat Medical Center from June 2002 to January 2005 were included in the study. The ages of the patients ranged between 27 and 74 years (mean 56.8+/-10.3), and the ages of the controls ranged from 21 to 69 years (mean 53.4+/-12.7). There were squamous cell carcinoma (SCC) of larynx in 30 patients, SCC of hypo pharynx in three patients, and SCC of paranasal sinus in one patient. 18 of these patients were in the early stage, four patients in the advanced stage, and 14 patients in the metastatic stage. Histopathological diagnoses were carried out by biopsies in preoperative term and pathological examination of the specimens in postoperative term. The examination of lymphocyte sub groups was done by flow-cytometiric analysis.
Results: In the flow cytometry of peripheral blood samples of head and neck cancer patients and controls, while the ratio of CD4+/CD8+ T cell significantly decreased, the ratio of B lymphocyte, NK cell and activated Tc cell increased in patients compared to the controls. When the patients were compared to each other, CD4+25+ cells were in high level in metastatic patients in comparison to patients in early stages.
Conclusion: These results indicated that especially cellular immune response was activated in head and neck cancer, but it was not enough to prevent the cancer


Immune response, head and neck cancer

Decrease in immunity in patients with cancer generally involved the alteration of immune competent cells in circulation. Cellular immunity plays an important role in controlling tumours. T-lymphocytes take on the main role in immune response against the tumours (1). In general, the deterioration of T-cell functions and the insufficiency of immune response against the tumour are valid in patients with cancer. The other reason of decreased immunity in these patients is the alteration of immune competent cells in circulation (2),(3),(4),(5). The immune system plays an important role in tumour growth and regression. The tumours may develop more frequently when the immune system is less active (5). Many tumours have lymphoid infiltrates. The immune system can limit the spread of tumours with different mechanisms. The aim of this study is to evaluate the cellular immune response in patients with head and neck cancer.

Material and Methods

Twenty volunteer healthy people as control and 34 patients with diagnoses of squamous cell carcinoma at the Department of Ear Nose Throat in Firat University Firat Medicine Center from June 2002 to January 2005 were included in this study. The ages of patients ranged from 27 to 74 years (mean 56.8+/-10.3), and the ages of controls ranged from 21 to 69 years (mean 53.4+/-12.7). There were squamous cell carcinoma (SCC) of larynx in 30 patients, SCC of hypopharynx in three patients, and SCC of paranasal sinus in one patient. Sixteen of these patients were in the early stage, four patients in the advanced stage, and 14 patients in the metastatic stage.

Histopathological diagnosis was carried out by biopsy material in pre- and post-operatively. Analysis by flow cytometry: The examination of lymphocyte subgroups was done by flow-cytometric analysis. For immunophenotypic analysis, 2 ml of peripheral blood samples were collected in glass tubes containing ethylenediaminetetraacetic acid (EDTA) and analyzed within one hour of collection. Lymphocyte (CD3+, CD4+, CD8+, CD19+, CD23+, CD25+, CD26+, and CD30+) cell rates were calculated by using flow cytometry conducted on a Coulter EPICS XL–MCL (Beckman Coulter, USA) using fluorescence-labelled (FITC or PE) monoclonal antibodies (Coulter Immunotech, France). Erythrocytes were removed from the peripheral blood sample in the EDTA tube by using the whole blood lysis method. Following erythrocyte removal, 5000 cells were counted in the appropriate gate for each tube and analyzed. Lymphocytes reacting with each monoclonal antibody were separated according to their fluorescence properties and their numbers reported as percentage.

Statistical analysis:
All the statistics were performed in SPSS version 10.01 software (SPSS, Inc., Chicago, IL, USA). Data were analyzed by using Independent- Samples t test, One Way analyses of ANOVA, and Tukey’s HSD test as needed. p <0.05 was considered to be significant.


In the flow cytometry of peripheral blood samples of cancer patients and controls, while the ratio of the CD4+/CD8+ T cell significantly decreased, the ratio of B-lymphocyte, NK cell, and activated Tc cell increased in patients compared to controls (Table/Fig 1). When the patients were compared to each other, CD4+25+ cells were observed to be in high level in patients with metastasis compared to patients in early stages (Table/Fig 2).


The effector mechanisms of both cell-mediated immunity and humoral immunity have been shown to kill tumour cells in vitro (6). The T-cell response is unquestionably the most important host response for the control of growth of antigenic tumour cells. It is responsible for both the direct killing of tumour cells and the activation of other components of the immune system. T-cell immunity to tumours reflects the function of the two T-cell subsets: class II-restricted T cells that largely represent CD4 helper T (TH) cells that mediate their effect by direct interaction with antigen-presenting cells (APC) and by the secretion of lymphokines to activate other effector cells and induce inflammatory responses and class I-restricted T cells that largely represent CD8+ cytotoxic T (Tc) cells that can also secrete lymphokines but mediate their effect mostly by direct lyses of tumour cells (7).
Cardi et al. (8) observed that lymphocytes extracted from subcutaneous metastasis were characterized by a significantly reduced ratio of CD4+ to CD8+ T cells as compared to peripheral blood lymphocytes from the same patients.
Gonzalez et al. (9) studied the functional response and phenotypic characterization of peripheral blood T-cells and their correlation with the clinical stage of disease in 29 males with previously untreated carcinoma of the larynx and 24 healthy male controls. Peripheral blood T cells, phenotypically CD2+, CD3+, were significantly decreased in patients relative to the controls. Mandel-Brown et al (10) reported that quantification of the T-lymphocyte subpopulation in peripheral blood did not indicate the presence of metastatic diseases. Significantly higher CD4/ CD8 ratio was present in lymph nodes containing metastatic disease compared to lymph nodes without metastatic disease.
Kuss et al.(11) determined a significantly lower absolute number of CD3+, CD4+, and CD8+ T cells in patients with head and neck squamous cell carcinoma (HNSCC) compared to normal controls (NC). However, no differences in the percentages of T-cell subsets between patients and NC were observed.
In the present study, we found a lower CD4/CD8 ratio in the study group. These findings indicate that increased CD8+ T lymphocytes (Tc) ratio has an important role in immunity developed against cancer.
NK cells can kill a wide range of tumour targets in vitro (7), especially cells that have reduced class I MHC expression and can escape killing by Tc (6). NK cells play a role in host defense against growth of tumour cells at both primary and metastatic sites (7).
Mickel et al. (12) evaluated peripheral blood lymphocyte and lymph node lymphocyte natural killer (NK) cell activity in 22 patients with head and neck squamous cell carcinoma. The peripheral blood lymphocyte NK activity of cancer patients was significantly less than controls.
Kou and Oi (13) indicated that the NK cell's activity in patients with laryngocarcinoma was lower than both the normal control group and the polyp of vocal cord patients group. They found that the more severe was the degree of disease, the lower the activity of the NK cell.
According to our result, the percentage of NK cells was higher (p<0.05). However, there is no difference in NK cells among early, advanced, and metastatic stage patients. B-lymphocytes have a potential role on tumour immunity producing tumour-reactive antibodies. Antibodies may mediate tumour cell lyses by both complement fixing and antibody dependent cellular cytotoxicity (ADCC). ADCC is a more potent lytic mechanism than complement mediated cytotoxicity (7).
Dawson et al.(2) documented no significant diffe


Badoual C, Hans S, Rodriguez J, Peyrard S, Klein C, Agueznay Nel H et al. Tumour-infiltrating CD4+ T-cell subpopulations in head and neck cancers. Clin Cancer Res. 2006;12 (2):465-72.
Dawson DE, Everts EC, Vetto RM, Burger DR. Assessment of immunocompetent cells in patients with head and neck squamous cell carcinoma. Ann Otol Rhinol Laryngol. 1985;94 (4 Pt 1):342-5.
Wolf GT, Lovett EJ 3rd, Peterson KA, Beauchamp ML, Baker SR. Lymphokine production and lymphocyte subpopulations in patients with head and neck squamous carcinoma. Arch Otolaryngol. 1984;110 (11):731-5.
Wolf GT, Carey TE. Tumour antigen phenotype, biologic staging, and prognosis in head and neck squamous carcinoma. J Natl Cancer Inst Monogr. 1992;(13):67-74.
Wanebo HJ, Blackinton D, Kouttab N, Mehta S. Contribution of serum inhibitory factors and immune cellular defects to the depressed cell-mediated immunity in patients with head and neck cancer. Am J Surg. 1993;166(4):389-94.
Abbas AK, Lichtman AH (eds). Immunity to Tumours: Immune Responses to Tumours. Cellular and Molecular Immunology. 5th ed. ELSEVIER Inc., Philadelphia; 2005: 400-402.
Greenberg PD. Mechanisms of Tumour Immunology. In: Parslow TG, Stites DP, Terr Al, Imboden JB,eds. Medical Immunology. 10th Lange/ McGraw-Hill Companies; 2001: 568-577.
Cardi G, Mastrangelo MJ, Berd D. Depletion of T-cells with the CD4+CD45R+ phenotype in lymphocytes that infiltrate subcutaneous metastases of human melanoma. Cancer Res. 1989; 49(23):6562-5.
Gonzalez FM, Vargas JA, Gea-Banacloche JC, Garcia JR, Berrocal E, Gorriz C et al. Functional and phenotypic analysis of T-lymphocytes in laryngeal carcinoma. Acta Otolaryngol.1994;114(6):663-8.
Mandell-Brown M, Johnson JT, Rabin BS, Hamill E, Wagner RL. Neck node immunoreactivity in head and neck carcinoma. Otolaryngol Head Neck Surg. 1986; 95(4):500-6.
Kuss I, Hathaway B, Ferris RL, Gooding W, Whiteside TL Imbalance in absolute counts of T lymphocyte subsets in patients with head and neck cancer and its relation to disease. Adv Otorhinolaryngol. 2005;62:161-72.
Tables and Figures
[Table / Fig - 1] [Table / Fig - 2]

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