Efficacy of Lignocaine Hydrochloride with Adrenaline, Clonidine and Dexmedetomidine for Surgical Removal of Impacted Mandibular Third Molar: A Research Protocol for a Randomised Clinical Trial
ZK01-ZK05
Correspondence
Akash Yogesh Doshi,
Sharad Pawar Dental College and Hospital, Datta Meghe Institutes of Medical Sciences, Wardha, Maharashtra, India.
E-mail: akashdoshi23@gmail.com
Introduction: In human dentition, the most common impacted teeth are Mandibular Third Molars (M3M). Removal or extraction of these teeth leads to anxiety in the patients oweing to the perception of pain. Thus, pain control mechanism like anaesthesia needs to be executed appropriately. Using newer local anaesthetic drugs minimises side-effects and drug interactions. Adrenaline is traditionally used vasoconstrictor along with Lignocaine. Dexmedetomidine and Clonidine are alpha agonists which in combination with Lignocaine provide a prolonged duration of anaesthesia thus decreasing the need for rescue analgesics.
Need of the study: This research will assist in assessing and establishing the duration of anaesthesia and postoperative analgesia after the administration of lignocaine hydrochloride with adrenaline, clonidine and dexmedetomidine in third molar surgery. This will eventually lead to less consumption of analgesics owing to the delay in ingestion of rescue analgesics.
Aim: To evaluate and compare the safety and efficacy of adrenaline, clonidine and dexmedetomidine as an adjuvant to lignocaine hydrochloride for perineural inferior alveolar nerve block in cases of Impacted Mandibular Third Molars (IM3M) surgeries.
Materials and Methods: This is a prospective, triple-blind, randomised, controlled, parallel arm study. The study will be conducted at the Department of Oral and Maxillofacial Surgery, Sharad Pawar Dental College and Hospital, Sawangi (M), Wardha, India, from February 2023 to June 2024. A total of 45 consecutive systemically healthy patients requiring unilateral surgical extraction of impacted M3M with similar orientations will be divided into three groups randomly. The first group will receive lignocaine with adrenaline, the second group will receive lignocaine with clonidine and third group will receive lignocaine with dexmedetomidine during the extraction procedure which will be compared on following parameters like the onset of anaesthesia, depth of anaesthesia, haemodynamic parameters and duration of postoperative analgesia. ‘One-way Analysis of Variance (ANOVA)’ will be used to analyse and evaluate.