MRI Findings in Osmotic Demyelination Syndrome- A Report of Two Cases
TD04-TD06
Correspondence
Vaishali Bodhraj Dhawan,
Associate Professor, Department of Radiology, JNMC, Sawangi Meghe, Wardha, Maharashtra, India.
E-mail: vaishalibdhawan@rediffmail.com
Osmotic Demyelination Syndrome (ODS) is a condition seen due to the loss of normal myelin in the central nervous system. Multiple etiologies have been identified as causing this condition, however, the most reported cause is the rapid correction of hyponatraemia. Different levels of the central nervous system are involved in the condition. Despite variable etiologies and clinical outcomes of the disease, the Magnetic Resonance Imaging (MRI) findings are well-established and characteristic. Hereby, two cases (45 years and 25 years old males) of ODS are described, to demonstrate the characteristic magnetic resonance imaging findings of the brain. Both cases were chronic alcoholics with a history of few episodes of vomiting, who later developed neurological symptoms. Their biochemical investigations showed severe hyponatraemia. The hyponatraemia was corrected rapidly, following which they developed neurological symptoms. Non contrast MRI brain was done for both patients, which showed abnormal hyperintense T2/Fluid-attenuated Inversion Recovery (FLAIR) signals in central Pons. Both cases showed variable, however characteristics findings of ODS on MRI. Despite, multiple causative factors and clinical outcomes of ODS, MRI with its characteristic findings plays a key role in diagnosis.