Rhupus Syndrome: An Overlap with Renal Complications SD01-SD02
Dr. Subal Kumar Pradhan,
Paediatric Nephrologist, Associate Professor, Department of Paediatrics Nephrology,
SVP Post Graduate Institute of Paediatrics and SCB Medical College,
Cuttack, Odisha, India.
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Rhupus syndrome is a rare condition of overlap of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) presenting with erosive polyarthritis and symptoms of SLE. It occasionally has renal involvement as its complication makes the diagnosis more difficult. Here the authors present a case of a 13-year-old female with severe arthritis, which gradually progressed into lupus nephritis with the presence of specific autoantibodies confirming the diagnosis of Rhupus. The child was managed with disease modifying anti-rheumatic drug (hydroxychloroquine), immunosuppressants (mycophenolate mofetil), steroid (prednisolone) and calcium channel blocker (amlodipine). Accurate diagnosis is the key for early detection since Rhupus is a very rare disorder with very limited reported cases.