Carcinosarcoma of the Uterus with Microcystic Elongated and Fragmented Pattern: A Rare Histopathological Entity ED01-ED03
Dr. Nimisha Sharma,
B4, 3067, Ridge View Appartments, Vasant Kunj-110070, New Delhi, India.
Carcinosarcomas of the uterus are rare, highly aggressive forms of biphasic tumours. These are monoclonal in origin with disproportionate percentage of mortality. This entity comprises of admixture of carcinomatous and sarcomatous elements. There are two histological subtypes based on the the sarcomatous components which can be either hetrerologous or homologous. In majority of uterine carcinosarcomas both the carcinomatous and sarcomatous elements are high grade. These can be associated with mesenchymal epithelial transition presenting as Microcystic Elongated and Fragmented Pattern (MELF) which is a rare and potential mimicker of vascular invasion. A, 62-year-old, female presented with complaints of vaginal bleeding and discharge for three months with a polypoidal mass in the cervix. Histopathology revealed a biphasic tumour consisting of epithelial and mesenchymal elements. Immunohistochemistry for PAN-CK, CK 19, p63, CEA, EMA, vimentin, ER, PR, Desmin, S100, SMA, CD 34 and CD10 along with HPV DNA on cervical swab was performed. Final diagnosis of carcinosarcoma with MELF was conferred. The case was highlighted due to its rarity and unique histological pattern.