Immune Response in Pregnant Women Infected with Acute Vaginal Abscess Caused by Staphylococcus aureus and Trichomonas vaginalis DC51-DC55
Dr. Ahmed Abduljabbar Jaloob Aljanaby,
Assistant Professor, Department of Biology, University of Kufa, Faculty of Science, Al-najaf, Iraq.
Introduction: Vaginal abscess in pregnant women caused by Staphylococcus aureus and Trichomonas vaginalis is one of the most important disease, this infection is still medically uncontrolled because of poor health awareness due to the absence of personal hygiene in some women.
Aim: This study is aimed add evaluation of immune response in pregnant women infected with acute vaginal abscess caused by S.aureus and T.vaginalis due to the determination of four biomarkers level; Interleukin13 (IL-13), Prostaglandin E2 (PGE2), Transforming growth factor ß1(TGF-ß1) and Lactoferrin.
Materials and Methods: This is a case control study was done in AL-Zahra hospital in AL-Najaf City, Iraq from January 2017 to November 2017. 120 pregnant women were included in this study, 30 women infected with S. aureus, 30 women infected with T. vaginalis, 30 women infected with both pathogens (inclusion criteria in this study) and 30 healthy pregnant women as control. All other cases were excluded from this study. Enzyme Linked Immunosorbent Assay (ELISA) technique was used in this study to estimate biomarkers level in serum of pregnant women infected with acute vaginal abscess.
Results: The results of the current study proved that there was significant increase (P <0.05) in IL-3, PGE2 and TGF-ß1 levels in serum of women infected with acute vaginal abscess caused by S.aureus, T.vaginalis and both pathogens as compared with control; while, there was significant decrease (P <0.05) in lactoferrin level in serum of pregnant women infected with T.vaginalis as compared with women infected with S.aureus and control.
Conclusion: The synergistically pathogenic effect of S.aureus and T.vaginalis in pregnant women infected with acute vaginal abscess lead to activation of T-cell and overproduction of IL-3, PGE2 and TGF-ß1 as a good signaling markers against infection. In contrast, this synergistic effect leads to reduction of lactoferrin level in the same women. That mean these women may be susceptible to acute anemia that may be lead to abortion.